The biphasic opening of the blood-brain barrier in the cortex and hippocampus after traumatic brain injury in rats

Mustafa K. Başkaya, A. Muralikrishna Rao, Aclan Doǧan, David Donaldson, Robert J. Dempsey

Research output: Contribution to journalArticle

214 Scopus citations

Abstract

This study examined the time course of the blood-brain barrier (BBB) opening and correlated this with brain edema formation after a lateral controlled cortical impact (CCI) brain injury in rats. Quantitative measurement of Evans-blue (EB) extravasation using fluorescence was employed at 2, 4, 6 h and 1, 2, 3, 4 and 7 days after injury. Brain edema was measured by specific gravity of the tissue at corresponding time points. Two prominent EB extravasations were observed at 4-6 h and 3-day after injury in the injury-site cortex and the ipsilateral hippocampus. Brain edema became progressively more severe over time and peaked at 24 h after injury and began to decline after day 3. These results suggest that there is a biphasic opening of the BBB after CCI brain injury and the second opening of the BBB does not contribute to a further increase in edema formation.

Original languageEnglish (US)
Pages (from-to)33-36
Number of pages4
JournalNeuroscience Letters
Volume226
Issue number1
DOIs
StatePublished - Apr 18 1997
Externally publishedYes

Keywords

  • Blood-brain barrier
  • Brain edema
  • Controlled cortical impact
  • Traumatic brain injury

ASJC Scopus subject areas

  • Neuroscience(all)

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