The biphasic opening of the blood-brain barrier in the cortex and hippocampus after traumatic brain injury in rats

Mustafa K. Başkaya, A. Muralikrishna Rao, Aclan Dogan, David Donaldson, Robert J. Dempsey

Research output: Contribution to journalArticle

198 Citations (Scopus)

Abstract

This study examined the time course of the blood-brain barrier (BBB) opening and correlated this with brain edema formation after a lateral controlled cortical impact (CCI) brain injury in rats. Quantitative measurement of Evans-blue (EB) extravasation using fluorescence was employed at 2, 4, 6 h and 1, 2, 3, 4 and 7 days after injury. Brain edema was measured by specific gravity of the tissue at corresponding time points. Two prominent EB extravasations were observed at 4-6 h and 3-day after injury in the injury-site cortex and the ipsilateral hippocampus. Brain edema became progressively more severe over time and peaked at 24 h after injury and began to decline after day 3. These results suggest that there is a biphasic opening of the BBB after CCI brain injury and the second opening of the BBB does not contribute to a further increase in edema formation.

Original languageEnglish (US)
Pages (from-to)33-36
Number of pages4
JournalNeuroscience Letters
Volume226
Issue number1
DOIs
StatePublished - Apr 18 1997
Externally publishedYes

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Blood-Brain Barrier
Hippocampus
Brain Edema
Evans Blue
Wounds and Injuries
Brain Injuries
Specific Gravity
Edema
Fluorescence
Traumatic Brain Injury

Keywords

  • Blood-brain barrier
  • Brain edema
  • Controlled cortical impact
  • Traumatic brain injury

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

The biphasic opening of the blood-brain barrier in the cortex and hippocampus after traumatic brain injury in rats. / Başkaya, Mustafa K.; Rao, A. Muralikrishna; Dogan, Aclan; Donaldson, David; Dempsey, Robert J.

In: Neuroscience Letters, Vol. 226, No. 1, 18.04.1997, p. 33-36.

Research output: Contribution to journalArticle

Başkaya, Mustafa K. ; Rao, A. Muralikrishna ; Dogan, Aclan ; Donaldson, David ; Dempsey, Robert J. / The biphasic opening of the blood-brain barrier in the cortex and hippocampus after traumatic brain injury in rats. In: Neuroscience Letters. 1997 ; Vol. 226, No. 1. pp. 33-36.
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