The AT2 angiotensin receptor subtype predominates in the 18 day gestation fetal rat brain

Vickie I. Cook; Kevin L. Grove; Kathleen M. McMenamin; Michele R. Carter; Joseph W. Harding; Robert C. Speth

doi:10.1016/0006-8993(91)91254-X

The AT₂ angiotensin receptor subtype predominates in the 18 day gestation fetal rat brain

Vickie I. Cook, Kevin L. Grove, Kathleen M. McMenamin, Michele R. Carter, Joseph W. Harding, Robert C. Speth

Research output: Contribution to journal › Article › peer-review

43 Scopus citations

Abstract

The angiotensin II receptor subtype-specific antagonists Dup 753 (AT₁) and PD 123177 (AT₂) were used to characterize the angiotensin II receptor subtypes present in 18 day gestation fetal Wistar-Kyoto (WKY) and spontaneously hypertensive (SHR) rat brain using in vitro receptor autoradiography. The AT₂ subtype was predominant in the brain of both rat strains, even in areas that display predominantly the AT₁ subtype in the adult rat brain.

Original language	English (US)
Pages (from-to)	334-336
Number of pages	3
Journal	Brain research
Volume	560
Issue number	1-2
DOIs	https://doi.org/10.1016/0006-8993(91)91254-X
State	Published - Sep 27 1991
Externally published	Yes

Keywords

Angiotensin receptor
Brain
Rat fetus
Subtype

ASJC Scopus subject areas

General Neuroscience
Molecular Biology
Clinical Neurology
Developmental Biology

Access to Document

10.1016/0006-8993(91)91254-X

Cite this

@article{f14d63f0712d44a792dcaee9b19ed0cd,

title = "The AT2 angiotensin receptor subtype predominates in the 18 day gestation fetal rat brain",

abstract = "The angiotensin II receptor subtype-specific antagonists Dup 753 (AT1) and PD 123177 (AT2) were used to characterize the angiotensin II receptor subtypes present in 18 day gestation fetal Wistar-Kyoto (WKY) and spontaneously hypertensive (SHR) rat brain using in vitro receptor autoradiography. The AT2 subtype was predominant in the brain of both rat strains, even in areas that display predominantly the AT1 subtype in the adult rat brain.",

keywords = "Angiotensin receptor, Brain, Rat fetus, Subtype",

author = "Cook, {Vickie I.} and Grove, {Kevin L.} and McMenamin, {Kathleen M.} and Carter, {Michele R.} and Harding, {Joseph W.} and Speth, {Robert C.}",

year = "1991",

month = sep,

day = "27",

doi = "10.1016/0006-8993(91)91254-X",

language = "English (US)",

volume = "560",

pages = "334--336",

journal = "Brain research",

issn = "0006-8993",

publisher = "Elsevier",

number = "1-2",

}

TY - JOUR

T1 - The AT2 angiotensin receptor subtype predominates in the 18 day gestation fetal rat brain

AU - Cook, Vickie I.

AU - Grove, Kevin L.

AU - McMenamin, Kathleen M.

AU - Carter, Michele R.

AU - Harding, Joseph W.

AU - Speth, Robert C.

PY - 1991/9/27

Y1 - 1991/9/27

N2 - The angiotensin II receptor subtype-specific antagonists Dup 753 (AT1) and PD 123177 (AT2) were used to characterize the angiotensin II receptor subtypes present in 18 day gestation fetal Wistar-Kyoto (WKY) and spontaneously hypertensive (SHR) rat brain using in vitro receptor autoradiography. The AT2 subtype was predominant in the brain of both rat strains, even in areas that display predominantly the AT1 subtype in the adult rat brain.

AB - The angiotensin II receptor subtype-specific antagonists Dup 753 (AT1) and PD 123177 (AT2) were used to characterize the angiotensin II receptor subtypes present in 18 day gestation fetal Wistar-Kyoto (WKY) and spontaneously hypertensive (SHR) rat brain using in vitro receptor autoradiography. The AT2 subtype was predominant in the brain of both rat strains, even in areas that display predominantly the AT1 subtype in the adult rat brain.

KW - Angiotensin receptor

KW - Brain

KW - Rat fetus

KW - Subtype

UR - http://www.scopus.com/inward/record.url?scp=0025918127&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0025918127&partnerID=8YFLogxK

U2 - 10.1016/0006-8993(91)91254-X

DO - 10.1016/0006-8993(91)91254-X

M3 - Article

C2 - 1760741

AN - SCOPUS:0025918127

SN - 0006-8993

VL - 560

SP - 334

EP - 336

JO - Brain research

JF - Brain research

IS - 1-2

ER -