The AT2 angiotensin receptor subtype predominates in the 18 day gestation fetal rat brain

Vickie I. Cook, Kevin L. Grove, Kathleen M. McMenamin, Michele R. Carter, Joseph W. Harding, Robert C. Speth

    Research output: Contribution to journalArticle

    40 Scopus citations

    Abstract

    The angiotensin II receptor subtype-specific antagonists Dup 753 (AT1) and PD 123177 (AT2) were used to characterize the angiotensin II receptor subtypes present in 18 day gestation fetal Wistar-Kyoto (WKY) and spontaneously hypertensive (SHR) rat brain using in vitro receptor autoradiography. The AT2 subtype was predominant in the brain of both rat strains, even in areas that display predominantly the AT1 subtype in the adult rat brain.

    Original languageEnglish (US)
    Pages (from-to)334-336
    Number of pages3
    JournalBrain research
    Volume560
    Issue number1-2
    DOIs
    StatePublished - Sep 27 1991

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    Keywords

    • Angiotensin receptor
    • Brain
    • Rat fetus
    • Subtype

    ASJC Scopus subject areas

    • Neuroscience(all)
    • Molecular Biology
    • Clinical Neurology
    • Developmental Biology

    Cite this

    Cook, V. I., Grove, K. L., McMenamin, K. M., Carter, M. R., Harding, J. W., & Speth, R. C. (1991). The AT2 angiotensin receptor subtype predominates in the 18 day gestation fetal rat brain. Brain research, 560(1-2), 334-336. https://doi.org/10.1016/0006-8993(91)91254-X