The Association Between Trabecular Bone Score and Lumbar Spine Volumetric BMD Is Attenuated Among Older Men With High Body Mass Index

Lisa Langsetmo, Tien N. Vo, Kristine E. Ensrud, Brent C. Taylor, Peggy M. Cawthon, Ann V. Schwartz, Douglas C. Bauer, Eric Orwoll, Nancy E. Lane, Elizabeth Barrett-Connor, John T. Schousboe

Research output: Contribution to journalArticle

22 Scopus citations

Abstract

Trabecular bone score (TBS) has been proposed as a dual-energy X-ray absorptiometry (DXA) derived measure of underlying quality of trabecular bone; however, TBS is not considered valid for those with body mass index (BMI) >37kg/m2. Our objective was to determine the association between TBS and lumbar spine (trabecular) volumetric BMD (LS-VBMD) and to examine whether the association varied by BMI and body composition among older men below this clinical threshold. We used regression models to study 3479 men age ≥65 years enrolled in the Osteoporotic Fractures in Men (MrOS) study who had TBS from spine DXA scans, LS-VBMD from central quantitative computed tomography, measures of trunk fat and lean mass from DXA, and BMI 2. TBS was categorized as normal (n=925), partially degraded (n=1747), and degraded (n=807). TBS was inversely related to BMI, trunk fat mass, and trunk lean mass (all p

Original languageEnglish (US)
JournalJournal of Bone and Mineral Research
DOIs
StateAccepted/In press - 2016

Keywords

  • Body mass index
  • Bone mineral density
  • Osteoporosis
  • Trabecular bone score

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine
  • Endocrinology, Diabetes and Metabolism

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    Langsetmo, L., Vo, T. N., Ensrud, K. E., Taylor, B. C., Cawthon, P. M., Schwartz, A. V., Bauer, D. C., Orwoll, E., Lane, N. E., Barrett-Connor, E., & Schousboe, J. T. (Accepted/In press). The Association Between Trabecular Bone Score and Lumbar Spine Volumetric BMD Is Attenuated Among Older Men With High Body Mass Index. Journal of Bone and Mineral Research. https://doi.org/10.1002/jbmr.2867