The association between congenital diaphragmatic hernia and undescended testes

Kenneth S. Azarow, Robert Cusick, Julia Wynn, Wendy Chung, George B. Mychaliska, Timothy M. Crombleholme, Dai H. Chung, Foong Yen Lim, Douglas Potoka, Brad W. Warner, Gundrun Aspelund, Marc S. Arkovitz

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Background Undescended testes (UDT) is a common abnormality treated by pediatric surgeons. Embryological development of the genitourinary ridge is in close proximity with the pleuroperitoneal fold. The purpose of this paper is to describe the association between congenital diaphragmatic hernia (CDH) and UDT. Materials/methods As part of the DHREAMS (Diaphragmatic Hernia Research and Exploration: Advancing Molecular Science) study (www.cdhgenetics.com), all living children had tissue banked and analyzed for common genetic mutations and had a health assessment performed by telephone consultation with the parents at two years of age. The incidence of UDT was then compared to clinical and genetic findings previously identified. Results Sixty-five males had complete information from their 2 year health assessment. Of these, twelve (18%) had a UDT repaired by the time of the 2 year assessment. Of the twelve who had a repair, no child had a unilateral UDT which was contralateral to the side of the CDH. There were no differences in rate or number of mutations of any of the genes we checked as part of our study. Conclusion It appears that a deficiency of diaphragm tissue may affect the first or transabdominal phase of the testicular descent, leading to an increased incidence of UDT.

Original languageEnglish (US)
Pages (from-to)744-745
Number of pages2
JournalJournal of pediatric surgery
Volume50
Issue number5
DOIs
StatePublished - May 1 2015

Keywords

  • Congenital diaphragmatic hernia (CDH)
  • Cryptorchidism Survival
  • ECMO
  • Undescended testicle (UDT)

ASJC Scopus subject areas

  • Surgery
  • Pediatrics, Perinatology, and Child Health

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