The arcuate nucleus and the control of gonadotropin and prolactin secretion in the female rhesus monkey (Macaca mulatta)

T. M. Plant, L. C. Krey, J. Moossy, J. T. McCormack, David Hess, E. Knobil

Research output: Contribution to journalArticle

134 Citations (Scopus)

Abstract

Attempts were made to destroy selectively the arcuate nucleus with radiofrequency current in adult female rhesus monkeys as a first step in identifying the areas of the mediobasal hypothalamus (MBH) that are responsible for the neural control of gonadotropin secretion in this species. Extensive or complete destruction of the arcuate region was produced in three animals and in two of these the lesion was confined primarily to the arcuate region and the dorsal aspect of the posterior median eminence. These lesions resulted in the cessation of LH and FSH secretion and blocked the positive feedback action of estradiol on gonadotropin release but did not appear to influence grossly basal thyroid and adrenocortical function, or to abolish GH discharge in response to insulin hypoglycemia. Adenohypophysial infarcts were not observed and exogenous LHRH and TRH induced marked discharges of the appropriate anterior pituitary hormones. In two additional animals with large hypothalamic lesions, destruction of the arcuate region was incomplete. In this group only partial inhibition of gonadotropin secretion was observed. LH and FSH secretion did not appear to be influenced in one animal bearing a large MBH lesion that entirely spared the arcuate region. Although serum prolactin remained at pre-lesion control levels after placement of the two relatively discrete lesions confined to the arcuate region, unambiguous increases in the secretion of this hormone were observed when the area of destruction encompassed tissue anterior and/or dorsal to the arcuate region. These observations suggest that the arcuate region is the primary structure mediating the hypothalamic control of gonadotropin secretion in the rhesus monkey. They also suggest that, in this species, the regions of the MBH involved with the regulation of gonadotropin release and those which control prolactin secretion are anatomically distinct.

Original languageEnglish (US)
Pages (from-to)52-62
Number of pages11
JournalEndocrinology
Volume102
Issue number1
StatePublished - 1978
Externally publishedYes

Fingerprint

Arcuate Nucleus of Hypothalamus
Macaca mulatta
Gonadotropins
Prolactin
Hypothalamus
Anterior Pituitary Hormones
Median Eminence
Hypoglycemia
Gonadotropin-Releasing Hormone
Estradiol
Thyroid Gland
Hormones
Insulin
Serum

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

Cite this

Plant, T. M., Krey, L. C., Moossy, J., McCormack, J. T., Hess, D., & Knobil, E. (1978). The arcuate nucleus and the control of gonadotropin and prolactin secretion in the female rhesus monkey (Macaca mulatta). Endocrinology, 102(1), 52-62.

The arcuate nucleus and the control of gonadotropin and prolactin secretion in the female rhesus monkey (Macaca mulatta). / Plant, T. M.; Krey, L. C.; Moossy, J.; McCormack, J. T.; Hess, David; Knobil, E.

In: Endocrinology, Vol. 102, No. 1, 1978, p. 52-62.

Research output: Contribution to journalArticle

Plant, TM, Krey, LC, Moossy, J, McCormack, JT, Hess, D & Knobil, E 1978, 'The arcuate nucleus and the control of gonadotropin and prolactin secretion in the female rhesus monkey (Macaca mulatta)', Endocrinology, vol. 102, no. 1, pp. 52-62.
Plant, T. M. ; Krey, L. C. ; Moossy, J. ; McCormack, J. T. ; Hess, David ; Knobil, E. / The arcuate nucleus and the control of gonadotropin and prolactin secretion in the female rhesus monkey (Macaca mulatta). In: Endocrinology. 1978 ; Vol. 102, No. 1. pp. 52-62.
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