The arabinitol appearance rate in laboratory animals and humans: Estimation from the arabinitol/creatinine ratio and relevance to the diagnosis of candidiasis

Brian Wong, E. M. Bernard, J. W M Gold, D. Fong, D. Armstrong

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

The effects of renal function on serum concentrations of the candidal metabolite arabinitol were studied by examining the accumulation elimination of arabinitol in animals and humans. Serum concentrations of arabinitol rose sharply and in direct proportion to creatinine concentrations after nephrectomy in rats. The serum half-life of exogenous arabinitol was 20.8 hr hr in anephric rats but only 0.62 hr in sham nephrectomized control animals. The mean ± SD apparent space of distribution of arabinitol was 419 ± 26 ml/kg. The fraction of exogenously administered arabinitol recovered in the urine was 0.73 ± 0.13 in uremic rats, 0.85 ± 0.28 in control rats, and 0.95 ± 0.10 in normal dogs. The arabinitol/creatinine clearance ratio was 0.99 ± 0.08 in normal dogs and 0.99 ± 0.25 in 22 critically ill patients with cancer. Thus arabinitol is eliminated by nearly quantitative urinary excretion and is cleared at virtually the same rate as creatinine. Therefore, the rate of arabinitol appearance in the body from any source equals the urinary arabinitol excretion rate and is directly proportional to the concentration ratio of arabinitol to creatinine in serum or urine.

Original languageEnglish (US)
Pages (from-to)353-359
Number of pages7
JournalJournal of Infectious Diseases
Volume146
Issue number3
StatePublished - 1982
Externally publishedYes

Fingerprint

Candidiasis
Laboratory Animals
Creatinine
Serum
Urine
Dogs
Nephrectomy
Critical Illness
Half-Life
Kidney
Neoplasms

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Immunology

Cite this

The arabinitol appearance rate in laboratory animals and humans : Estimation from the arabinitol/creatinine ratio and relevance to the diagnosis of candidiasis. / Wong, Brian; Bernard, E. M.; Gold, J. W M; Fong, D.; Armstrong, D.

In: Journal of Infectious Diseases, Vol. 146, No. 3, 1982, p. 353-359.

Research output: Contribution to journalArticle

@article{7b8c77cc0d7b4709a45e8c07fbc665b3,
title = "The arabinitol appearance rate in laboratory animals and humans: Estimation from the arabinitol/creatinine ratio and relevance to the diagnosis of candidiasis",
abstract = "The effects of renal function on serum concentrations of the candidal metabolite arabinitol were studied by examining the accumulation elimination of arabinitol in animals and humans. Serum concentrations of arabinitol rose sharply and in direct proportion to creatinine concentrations after nephrectomy in rats. The serum half-life of exogenous arabinitol was 20.8 hr hr in anephric rats but only 0.62 hr in sham nephrectomized control animals. The mean ± SD apparent space of distribution of arabinitol was 419 ± 26 ml/kg. The fraction of exogenously administered arabinitol recovered in the urine was 0.73 ± 0.13 in uremic rats, 0.85 ± 0.28 in control rats, and 0.95 ± 0.10 in normal dogs. The arabinitol/creatinine clearance ratio was 0.99 ± 0.08 in normal dogs and 0.99 ± 0.25 in 22 critically ill patients with cancer. Thus arabinitol is eliminated by nearly quantitative urinary excretion and is cleared at virtually the same rate as creatinine. Therefore, the rate of arabinitol appearance in the body from any source equals the urinary arabinitol excretion rate and is directly proportional to the concentration ratio of arabinitol to creatinine in serum or urine.",
author = "Brian Wong and Bernard, {E. M.} and Gold, {J. W M} and D. Fong and D. Armstrong",
year = "1982",
language = "English (US)",
volume = "146",
pages = "353--359",
journal = "Journal of Infectious Diseases",
issn = "0022-1899",
publisher = "Oxford University Press",
number = "3",

}

TY - JOUR

T1 - The arabinitol appearance rate in laboratory animals and humans

T2 - Estimation from the arabinitol/creatinine ratio and relevance to the diagnosis of candidiasis

AU - Wong, Brian

AU - Bernard, E. M.

AU - Gold, J. W M

AU - Fong, D.

AU - Armstrong, D.

PY - 1982

Y1 - 1982

N2 - The effects of renal function on serum concentrations of the candidal metabolite arabinitol were studied by examining the accumulation elimination of arabinitol in animals and humans. Serum concentrations of arabinitol rose sharply and in direct proportion to creatinine concentrations after nephrectomy in rats. The serum half-life of exogenous arabinitol was 20.8 hr hr in anephric rats but only 0.62 hr in sham nephrectomized control animals. The mean ± SD apparent space of distribution of arabinitol was 419 ± 26 ml/kg. The fraction of exogenously administered arabinitol recovered in the urine was 0.73 ± 0.13 in uremic rats, 0.85 ± 0.28 in control rats, and 0.95 ± 0.10 in normal dogs. The arabinitol/creatinine clearance ratio was 0.99 ± 0.08 in normal dogs and 0.99 ± 0.25 in 22 critically ill patients with cancer. Thus arabinitol is eliminated by nearly quantitative urinary excretion and is cleared at virtually the same rate as creatinine. Therefore, the rate of arabinitol appearance in the body from any source equals the urinary arabinitol excretion rate and is directly proportional to the concentration ratio of arabinitol to creatinine in serum or urine.

AB - The effects of renal function on serum concentrations of the candidal metabolite arabinitol were studied by examining the accumulation elimination of arabinitol in animals and humans. Serum concentrations of arabinitol rose sharply and in direct proportion to creatinine concentrations after nephrectomy in rats. The serum half-life of exogenous arabinitol was 20.8 hr hr in anephric rats but only 0.62 hr in sham nephrectomized control animals. The mean ± SD apparent space of distribution of arabinitol was 419 ± 26 ml/kg. The fraction of exogenously administered arabinitol recovered in the urine was 0.73 ± 0.13 in uremic rats, 0.85 ± 0.28 in control rats, and 0.95 ± 0.10 in normal dogs. The arabinitol/creatinine clearance ratio was 0.99 ± 0.08 in normal dogs and 0.99 ± 0.25 in 22 critically ill patients with cancer. Thus arabinitol is eliminated by nearly quantitative urinary excretion and is cleared at virtually the same rate as creatinine. Therefore, the rate of arabinitol appearance in the body from any source equals the urinary arabinitol excretion rate and is directly proportional to the concentration ratio of arabinitol to creatinine in serum or urine.

UR - http://www.scopus.com/inward/record.url?scp=0019954217&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0019954217&partnerID=8YFLogxK

M3 - Article

C2 - 7108282

AN - SCOPUS:0019954217

VL - 146

SP - 353

EP - 359

JO - Journal of Infectious Diseases

JF - Journal of Infectious Diseases

SN - 0022-1899

IS - 3

ER -