The amplitude of endogenous melatonin production is not affected by melatonin treatment in humans

Miki Matsumoto, Robert L. Sack, Mary L. Blood, Alfred J. Lewy

Research output: Contribution to journalArticle

17 Scopus citations

Abstract

A physiological dose of melatonin (0.5 mg) or placebo was given at bedtime to night shift workers (n=21) for seven days, and endogenous melatonin profiles were measured on the eighth day. The amplitude of endogenous melatonin secretion was unchanged by treatment. Also, a melatonin treatment trial using a 50 mg daily bedtime dose for 37 days to a blind subject resulted in no change in the endogenous melatonin profile. We conclude that circulating melatonin can shift the phase, but does not alter the amplitude, of pineal melatonin secretion.

Original languageEnglish (US)
Pages (from-to)42-44
Number of pages3
JournalJournal of pineal research
Volume22
Issue number1
DOIs
StatePublished - Jan 1997

Keywords

  • Blindness
  • Circadian rhythms
  • Melatonin

ASJC Scopus subject areas

  • Endocrinology

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