The -137G/C polymorphism of interleukin 18 promoter and risk of HIV-1 infection and its progression to AIDS

R. C. Sobti, V. L. Sharma, A. M. Abitew, N. Berhane, S. A. Mahdi, M. Askari, V. S. Kuttiat, Ajay Wanchu

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

A growing body of evidence suggests that host genetic factors play an important role both in susceptibility to human immunodeficiency virus 1 (HIV-1) infection and in progression to AIDS. Interleukin 18 (IL-18) is a pleiotropic proinflammatory cytokine that serves as an important regulator of immune responses. It plays a key role in induction of both Th1 and Th2 cytokines and, thereby, modulates their immune responses. Single nucleotide polymorphisms in the IL-18 gene promoter region may lead to an altered transcriptional activity and IL-18 production, and so this may account for individuals' variation to the risk of HIV-1 infection. With this perspective, the -137G/C polymorphism in the promoter region of the IL-18 gene was studied in 500 patients with HIV-1/AIDS and an equal number of sex and age matched healthy controls using sequence specific polymerase chain reaction analysis. We did not observe any significant association of the heterozygous G/C genotype with the risk of HIV-1-infection/AIDS. However, statistically significant associations of the G allele and homozygous G/G genotype of -137 G/C polymorphism of IL-18 promoter with increased risk of HIV-1/ AIDS were identified. The data of the present study suggest that IL-18 -137 G allele and G/G genotype seem to be involved in the pathogenesis of HIV-1 infection among North Indians.

Original languageEnglish (US)
Pages (from-to)353-356
Number of pages4
JournalActa Virologica
Volume55
Issue number4
DOIs
StatePublished - 2011
Externally publishedYes

Fingerprint

Interleukin-18
Virus Diseases
HIV-1
Acquired Immunodeficiency Syndrome
Genotype
Genetic Promoter Regions
Alleles
Cytokines
Genes
Single Nucleotide Polymorphism
Polymerase Chain Reaction

Keywords

  • HIV-1/AIDS
  • IL-18 gene
  • PCR
  • SNP

ASJC Scopus subject areas

  • Virology
  • Infectious Diseases

Cite this

Sobti, R. C., Sharma, V. L., Abitew, A. M., Berhane, N., Mahdi, S. A., Askari, M., ... Wanchu, A. (2011). The -137G/C polymorphism of interleukin 18 promoter and risk of HIV-1 infection and its progression to AIDS. Acta Virologica, 55(4), 353-356. https://doi.org/10.4149/av_2011_04_353

The -137G/C polymorphism of interleukin 18 promoter and risk of HIV-1 infection and its progression to AIDS. / Sobti, R. C.; Sharma, V. L.; Abitew, A. M.; Berhane, N.; Mahdi, S. A.; Askari, M.; Kuttiat, V. S.; Wanchu, Ajay.

In: Acta Virologica, Vol. 55, No. 4, 2011, p. 353-356.

Research output: Contribution to journalArticle

Sobti, RC, Sharma, VL, Abitew, AM, Berhane, N, Mahdi, SA, Askari, M, Kuttiat, VS & Wanchu, A 2011, 'The -137G/C polymorphism of interleukin 18 promoter and risk of HIV-1 infection and its progression to AIDS', Acta Virologica, vol. 55, no. 4, pp. 353-356. https://doi.org/10.4149/av_2011_04_353
Sobti, R. C. ; Sharma, V. L. ; Abitew, A. M. ; Berhane, N. ; Mahdi, S. A. ; Askari, M. ; Kuttiat, V. S. ; Wanchu, Ajay. / The -137G/C polymorphism of interleukin 18 promoter and risk of HIV-1 infection and its progression to AIDS. In: Acta Virologica. 2011 ; Vol. 55, No. 4. pp. 353-356.
@article{4be00506e3c24a72870aa9d4bf4896e3,
title = "The -137G/C polymorphism of interleukin 18 promoter and risk of HIV-1 infection and its progression to AIDS",
abstract = "A growing body of evidence suggests that host genetic factors play an important role both in susceptibility to human immunodeficiency virus 1 (HIV-1) infection and in progression to AIDS. Interleukin 18 (IL-18) is a pleiotropic proinflammatory cytokine that serves as an important regulator of immune responses. It plays a key role in induction of both Th1 and Th2 cytokines and, thereby, modulates their immune responses. Single nucleotide polymorphisms in the IL-18 gene promoter region may lead to an altered transcriptional activity and IL-18 production, and so this may account for individuals' variation to the risk of HIV-1 infection. With this perspective, the -137G/C polymorphism in the promoter region of the IL-18 gene was studied in 500 patients with HIV-1/AIDS and an equal number of sex and age matched healthy controls using sequence specific polymerase chain reaction analysis. We did not observe any significant association of the heterozygous G/C genotype with the risk of HIV-1-infection/AIDS. However, statistically significant associations of the G allele and homozygous G/G genotype of -137 G/C polymorphism of IL-18 promoter with increased risk of HIV-1/ AIDS were identified. The data of the present study suggest that IL-18 -137 G allele and G/G genotype seem to be involved in the pathogenesis of HIV-1 infection among North Indians.",
keywords = "HIV-1/AIDS, IL-18 gene, PCR, SNP",
author = "Sobti, {R. C.} and Sharma, {V. L.} and Abitew, {A. M.} and N. Berhane and Mahdi, {S. A.} and M. Askari and Kuttiat, {V. S.} and Ajay Wanchu",
year = "2011",
doi = "10.4149/av_2011_04_353",
language = "English (US)",
volume = "55",
pages = "353--356",
journal = "Acta Virologica",
issn = "0001-723X",
publisher = "AEP - Academic Electronic Press Ltd.",
number = "4",

}

TY - JOUR

T1 - The -137G/C polymorphism of interleukin 18 promoter and risk of HIV-1 infection and its progression to AIDS

AU - Sobti, R. C.

AU - Sharma, V. L.

AU - Abitew, A. M.

AU - Berhane, N.

AU - Mahdi, S. A.

AU - Askari, M.

AU - Kuttiat, V. S.

AU - Wanchu, Ajay

PY - 2011

Y1 - 2011

N2 - A growing body of evidence suggests that host genetic factors play an important role both in susceptibility to human immunodeficiency virus 1 (HIV-1) infection and in progression to AIDS. Interleukin 18 (IL-18) is a pleiotropic proinflammatory cytokine that serves as an important regulator of immune responses. It plays a key role in induction of both Th1 and Th2 cytokines and, thereby, modulates their immune responses. Single nucleotide polymorphisms in the IL-18 gene promoter region may lead to an altered transcriptional activity and IL-18 production, and so this may account for individuals' variation to the risk of HIV-1 infection. With this perspective, the -137G/C polymorphism in the promoter region of the IL-18 gene was studied in 500 patients with HIV-1/AIDS and an equal number of sex and age matched healthy controls using sequence specific polymerase chain reaction analysis. We did not observe any significant association of the heterozygous G/C genotype with the risk of HIV-1-infection/AIDS. However, statistically significant associations of the G allele and homozygous G/G genotype of -137 G/C polymorphism of IL-18 promoter with increased risk of HIV-1/ AIDS were identified. The data of the present study suggest that IL-18 -137 G allele and G/G genotype seem to be involved in the pathogenesis of HIV-1 infection among North Indians.

AB - A growing body of evidence suggests that host genetic factors play an important role both in susceptibility to human immunodeficiency virus 1 (HIV-1) infection and in progression to AIDS. Interleukin 18 (IL-18) is a pleiotropic proinflammatory cytokine that serves as an important regulator of immune responses. It plays a key role in induction of both Th1 and Th2 cytokines and, thereby, modulates their immune responses. Single nucleotide polymorphisms in the IL-18 gene promoter region may lead to an altered transcriptional activity and IL-18 production, and so this may account for individuals' variation to the risk of HIV-1 infection. With this perspective, the -137G/C polymorphism in the promoter region of the IL-18 gene was studied in 500 patients with HIV-1/AIDS and an equal number of sex and age matched healthy controls using sequence specific polymerase chain reaction analysis. We did not observe any significant association of the heterozygous G/C genotype with the risk of HIV-1-infection/AIDS. However, statistically significant associations of the G allele and homozygous G/G genotype of -137 G/C polymorphism of IL-18 promoter with increased risk of HIV-1/ AIDS were identified. The data of the present study suggest that IL-18 -137 G allele and G/G genotype seem to be involved in the pathogenesis of HIV-1 infection among North Indians.

KW - HIV-1/AIDS

KW - IL-18 gene

KW - PCR

KW - SNP

UR - http://www.scopus.com/inward/record.url?scp=84855962963&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84855962963&partnerID=8YFLogxK

U2 - 10.4149/av_2011_04_353

DO - 10.4149/av_2011_04_353

M3 - Article

C2 - 22149501

AN - SCOPUS:84855962963

VL - 55

SP - 353

EP - 356

JO - Acta Virologica

JF - Acta Virologica

SN - 0001-723X

IS - 4

ER -