Testosterone synthesis in rhesus fetal testes: Comparison between middle and late gestation

W. E. Ellinwood, R. M. Brenner, David Hess, J. A. Resko

    Research output: Contribution to journalArticle

    29 Citations (Scopus)

    Abstract

    Several aspects of testosterone synthesis were examined in fetal testes of rhesus monkeys at middle (Days 79 to 82) and late gestation (Days 140 to 149). Histological examination of fetal testes revealed that Leydig cells are smaller at late gestation and that there are approximately one-third as many Leydig cells per unit area compared with midgestation. The concentration of testosterone in umbilical arterial serum, however, was not significantly lower at late gestation. In vitro synthesis of testosterone and cycle AMP (cAMP) was stimulated by human chorionic gonadotropin (hCG) in tissues collected at both stages of gestation. The testosterone concentration of testicular tissue and testosterone synthesis in the absence of hCG were ~2-fold greater at mid-gestation (P

    Original languageEnglish (US)
    Pages (from-to)955-963
    Number of pages9
    JournalBiology of Reproduction
    Volume22
    Issue number4
    StatePublished - 1980

    Fingerprint

    Testosterone
    Testis
    Pregnancy
    Leydig Cells
    Chorionic Gonadotropin
    Umbilicus
    Adenosine Monophosphate
    Macaca mulatta
    Serum

    ASJC Scopus subject areas

    • Cell Biology
    • Developmental Biology
    • Embryology

    Cite this

    Ellinwood, W. E., Brenner, R. M., Hess, D., & Resko, J. A. (1980). Testosterone synthesis in rhesus fetal testes: Comparison between middle and late gestation. Biology of Reproduction, 22(4), 955-963.

    Testosterone synthesis in rhesus fetal testes : Comparison between middle and late gestation. / Ellinwood, W. E.; Brenner, R. M.; Hess, David; Resko, J. A.

    In: Biology of Reproduction, Vol. 22, No. 4, 1980, p. 955-963.

    Research output: Contribution to journalArticle

    Ellinwood, WE, Brenner, RM, Hess, D & Resko, JA 1980, 'Testosterone synthesis in rhesus fetal testes: Comparison between middle and late gestation', Biology of Reproduction, vol. 22, no. 4, pp. 955-963.
    Ellinwood, W. E. ; Brenner, R. M. ; Hess, David ; Resko, J. A. / Testosterone synthesis in rhesus fetal testes : Comparison between middle and late gestation. In: Biology of Reproduction. 1980 ; Vol. 22, No. 4. pp. 955-963.
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