Terminal decline and markers of cerebro- and cardiovascular disease

Findings from a longitudinal study of the oldest old

Linda B. Hassing, Boo Johansson, Stig Berg, Sven E. Nilsson, Nancy L. Pedersen, Scott Hofer, Gerald McClearn

Research output: Contribution to journalArticle

41 Citations (Scopus)

Abstract

The purpose of this study was to examine the cognition-survival relationship among nondemented individuals in late life. The longitudinal design included three examinations at 2-year intervals. At baseline, 466 individuals (age range = 80-98) were examined. During the 6 years of follow-up, 206 individuals died. Four survival groups were defined on the basis of mortality prior to the subsequent measurement occasion. Tests of cognitive functioning encompassed the domains of crystallized knowledge, inductive reasoning, visuospatial ability, short-term memory, episodic memory, and speed. Significant associations were found between cognitive performance at baseline and subsequent survival. After adjusting for stroke and markers of cardiovascular disease, the authors found that only three out of six cognitive domains remained significant predictors of survival. The longitudinal analyses revealed limited evidence for an accelerated decline prior to death. The main results suggest that level of cognitive performance in late life is associated with proximity to death, that this relationship is longstanding, and that it is partially influenced by compromised cardio- and cerebrovascular functioning.

Original languageEnglish (US)
JournalJournals of Gerontology - Series B Psychological Sciences and Social Sciences
Volume57
Issue number3
StatePublished - 2002
Externally publishedYes

Fingerprint

Cerebrovascular Disorders
Longitudinal Studies
longitudinal study
Cardiovascular Diseases
Disease
Aptitude
Episodic Memory
Short-Term Memory
Cognition
death
Stroke
stroke
performance
Mortality
cognition
mortality
examination
ability
evidence
Group

ASJC Scopus subject areas

  • Geriatrics and Gerontology
  • Aging
  • Psychology(all)

Cite this

Terminal decline and markers of cerebro- and cardiovascular disease : Findings from a longitudinal study of the oldest old. / Hassing, Linda B.; Johansson, Boo; Berg, Stig; Nilsson, Sven E.; Pedersen, Nancy L.; Hofer, Scott; McClearn, Gerald.

In: Journals of Gerontology - Series B Psychological Sciences and Social Sciences, Vol. 57, No. 3, 2002.

Research output: Contribution to journalArticle

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