Temperature modulates ethanol sensitivity in mice: Generality across strain and sex

R. L. Alkana, D. A. Finn, G. G. Galleisky, M. Bejanian, D. C. Boone, B. Jones, P. J. Syapin

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

Findings in our laboratory indicate that body temperature alters ethanol potency as measured by sleep-time, wake-up brain ethanol concentration and mortality in male C57BL/6J mice. The current studies tested the generality of these results. Experiment one tested age-matched, drug-naive, male C57BL/6S and BALB/cS mice. Experiment two tested age-matched, drug-naive, male and female C57BL/6J mice. Each mouse was injected IP with 3.6 g/kg ethanol (20% w/v). After losing its righting reflex, the mouse was placed into a v-shaped sleep tray within a chamber kept at a designated temperature from 12 to 36°C. Upon awakening, rectal temperature was measured and blood and brain samples were taken for gas chromatographic analysis. As in previous studies, ambient temperature modulated the body temperatures and sleep-times of intoxicated animals. More important, wake-up rectal temperatures were positively correlated with sleep-times and negatively correlated with wake-up ethanol concentrations in all animals tested. These results support the hypothesis that brain sensitivity to ethanol depression varies with body temperature in accordance with membrane perturbation theories of anesthesia.

Original languageEnglish (US)
Pages (from-to)281-285
Number of pages5
JournalAlcohol
Volume2
Issue number2
DOIs
StatePublished - 1985

Keywords

  • C57BL/6 and BALB/c mice
  • Ethanol
  • Hypothermia
  • Male and female mice
  • Sleep-time
  • Temperature dependence of anesthesia
  • Theories of anesthesia

ASJC Scopus subject areas

  • Health(social science)
  • Biochemistry
  • Toxicology
  • Neurology
  • Behavioral Neuroscience

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  • Cite this

    Alkana, R. L., Finn, D. A., Galleisky, G. G., Bejanian, M., Boone, D. C., Jones, B., & Syapin, P. J. (1985). Temperature modulates ethanol sensitivity in mice: Generality across strain and sex. Alcohol, 2(2), 281-285. https://doi.org/10.1016/0741-8329(85)90060-6