TY - JOUR
T1 - Temperature affects ethanol lethality in C57BL/6, 129, LS and SS mice
AU - Finn, D. A.
AU - Bejanian, M.
AU - Jones, B. L.
AU - Syapin, P. J.
AU - Alkana, R. L.
N1 - Funding Information:
Supported by PHS Research Grant R01 AA05234 from the National Institute on Alcohol Abuse and Alcoholism (NIAAA) to R.L.A. The LS and SS mice were provided by the Institute for Behavioral Genetics, University of Colorado, Boulder, through a grant from NIAAA. We thank Leigh Kobayashi for figure preparation and assistance with the data analysis. A portion of these data was presented at the annual meeting of the Research Society on Alcoholism. June 1-5. 1988, in Charleston. SC (Alcohol.: Clin. Exp. Res. 12:309; 1988). This work was conducted as partial fulfillment of the requirements for the Degree of Doctor of Philosophy in Pharmaceutical Sciences, University of Southern California, School of Pharmacy (D.A.F.).
PY - 1989/10
Y1 - 1989/10
N2 - The effect of ambient and body temperature on ethanol lethality in inbred strains and selected lines of mice was investigated. C57BL/6J, 129/J, LS/Ibg and SS/Ibg mice were exposed to 23 or 34°C following IP injection of lethal ethanol doses (8.2, 6.0, 6.5 or 7.0 g/kg ethanol, respectively). All mice exposed to 23°C during intoxication became markedly hypothermic, with mean body temperatures dropping to lows of 27.9, 30.0, 33.0 and 33.3°C in C57, LS, SS and 129 animals, respectively. Compared to the 23°C groups, exposure to 34°C offset the ethanol-induced hypothermia and significantly increased percent mortality in all four mouse genotypes. Exposure to 34°C increased mortality at 24 hours postinjection from 15% to 95% in SS mice, from 37.5% to 100% in 129 mice and from 50% to 100% in LS and C57 mice. Blood ethanol data suggest that the present results cannot be explained by temperature-related changes in ethanol elimination. These results provide further evidence that body temperature during intoxication can have major effects on mortality rates in mice.
AB - The effect of ambient and body temperature on ethanol lethality in inbred strains and selected lines of mice was investigated. C57BL/6J, 129/J, LS/Ibg and SS/Ibg mice were exposed to 23 or 34°C following IP injection of lethal ethanol doses (8.2, 6.0, 6.5 or 7.0 g/kg ethanol, respectively). All mice exposed to 23°C during intoxication became markedly hypothermic, with mean body temperatures dropping to lows of 27.9, 30.0, 33.0 and 33.3°C in C57, LS, SS and 129 animals, respectively. Compared to the 23°C groups, exposure to 34°C offset the ethanol-induced hypothermia and significantly increased percent mortality in all four mouse genotypes. Exposure to 34°C increased mortality at 24 hours postinjection from 15% to 95% in SS mice, from 37.5% to 100% in 129 mice and from 50% to 100% in LS and C57 mice. Blood ethanol data suggest that the present results cannot be explained by temperature-related changes in ethanol elimination. These results provide further evidence that body temperature during intoxication can have major effects on mortality rates in mice.
KW - Body temperature
KW - Ethanol lethality
KW - Inbred strains of mice
KW - Selected lines of mice
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U2 - 10.1016/0091-3057(89)90329-8
DO - 10.1016/0091-3057(89)90329-8
M3 - Article
C2 - 2622994
AN - SCOPUS:0024358115
SN - 0091-3057
VL - 34
SP - 375
EP - 380
JO - Pharmacology, Biochemistry and Behavior
JF - Pharmacology, Biochemistry and Behavior
IS - 2
ER -