Temperament and externalizing behavior as mediators of genetic risk on adolescent substance use

Elisa M. Trucco, Brian M. Hicks, Sandra Villafuerte, Joel Nigg, Margit Burmeister, Robert A. Zucker

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Understanding how specific genes contribute to risk for addiction remains challenging. This study tests whether childhood temperament and externalizing behavior in early adolescence account for a portion of the association between specific genetic variants and substance use problems in late adolescence. The sample consisted of 487 adolescents from the Michigan Longitudinal Study, a high-risk sample (70.2% male, 81.7% European American ancestry). Polymorphisms across serotonergic (SLC6A4, 5-HTTLPR), dopaminergic (DRD4, u-VNTR), noradrenergic (SLC6A2, rs36021), and GABAergic (GABRA2, rs279858; GABRA6, rs3811995) genes were examined given prior support for associations with temperament, externalizing behavior, and substance use problems. The temperament traits behavioral control and resiliency were assessed using interviewer ratings (ages 9-11), and externalizing behavior (ages 12-14) was assessed using teacher ratings. Self-reported substance use outcomes (ages 15-17) included maximum alcoholic beverages consumed in 24 hours, and frequency of past year cigarette and marijuana use. Behavioral control, resiliency, and externalizing behavior accounted for the associations between polymorphisms in noradrenergic and GABAergic genes and substance use in late adolescence. Individual differences in emotional coping and behavioral regulation represent nonspecific neurobiological underpinnings for an externalizing pathway to addiction.

Original languageEnglish (US)
Pages (from-to)565-575
Number of pages11
JournalJournal of Abnormal Psychology
Volume125
Issue number4
DOIs
StatePublished - May 1 2016

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Temperament
Genes
Alcoholic Beverages
Cannabis
Individuality
Tobacco Products
Longitudinal Studies
Interviews
Genetic Risk
Mediator
Substance Use
Gene
Adolescence
Polymorphism
Addiction
Rating

ASJC Scopus subject areas

  • Clinical Psychology
  • Developmental and Educational Psychology
  • Arts and Humanities (miscellaneous)

Cite this

Temperament and externalizing behavior as mediators of genetic risk on adolescent substance use. / Trucco, Elisa M.; Hicks, Brian M.; Villafuerte, Sandra; Nigg, Joel; Burmeister, Margit; Zucker, Robert A.

In: Journal of Abnormal Psychology, Vol. 125, No. 4, 01.05.2016, p. 565-575.

Research output: Contribution to journalArticle

Trucco, Elisa M. ; Hicks, Brian M. ; Villafuerte, Sandra ; Nigg, Joel ; Burmeister, Margit ; Zucker, Robert A. / Temperament and externalizing behavior as mediators of genetic risk on adolescent substance use. In: Journal of Abnormal Psychology. 2016 ; Vol. 125, No. 4. pp. 565-575.
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