Telomere length and the risk of atrial fibrillation insights into the role of biological versus chronological aging

Jason D. Roberts, Thomas Dewland, James Longoria, Annette L. Fitzpatrick, Elad Ziv, Donglei Hu, Jue Lin, David V. Glidden, Bruce M. Psaty, Esteban G. Burchard, Elizabeth H. Blackburn, Jeffrey E. Olgin, Susan R. Heckbert, Gregory M. Marcus

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Background: Advanced age is the most important risk factor for atrial fibrillation (AF); however, the mechanism remains unknown. Telomeres, regions of DNA that shorten with cell division, are considered reliable markers of biological aging. We sought to examine the association between leukocyte telomere length (LTL) and incident AF in a large populationbased cohort using direct LTL measurements and genetic data. To further explore our findings, we compared atrial cell telomere length and LTL in cardiac surgery patients. Methods and Results: Mean LTL and the TERT rs2736100 single nucleotide polymorphism were assessed as predictors of incident AF in the Cardiovascular Health Study (CHS). Among the surgical patients, within subject comparison of atrial cell telomere length versus LTL was assessed. Among 1639 CHS participants, we observed no relationship between mean LTL and incident AF before and after adjustment for potential confounders (adjusted hazard ratio, 1.09; 95% confidence interval: 0.92-1.29; P=0.299); chronologic age remained strongly associated with AF in the same model. No association was observed between the TERT rs2736100 single nucleotide polymorphism and incident AF (adjusted hazard ratio: 0.95; 95% confidence interval: 0.88-1.04; P=0.265). In 35 cardiac surgery patients (26 with AF), atrial cell telomere length was longer than LTL (1.19±0.20 versus 1.02±0.25 [T/S ratio], P

Original languageEnglish (US)
Pages (from-to)1026-1032
Number of pages7
JournalCirculation: Arrhythmia and Electrophysiology
Volume7
Issue number6
DOIs
StatePublished - Dec 1 2014
Externally publishedYes

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Telomere
Atrial Fibrillation
Leukocytes
Thoracic Surgery
Single Nucleotide Polymorphism
Confidence Intervals
Health
Cell Division

Keywords

  • Aging
  • Atrial fibrillation
  • Genetics

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

Cite this

Telomere length and the risk of atrial fibrillation insights into the role of biological versus chronological aging. / Roberts, Jason D.; Dewland, Thomas; Longoria, James; Fitzpatrick, Annette L.; Ziv, Elad; Hu, Donglei; Lin, Jue; Glidden, David V.; Psaty, Bruce M.; Burchard, Esteban G.; Blackburn, Elizabeth H.; Olgin, Jeffrey E.; Heckbert, Susan R.; Marcus, Gregory M.

In: Circulation: Arrhythmia and Electrophysiology, Vol. 7, No. 6, 01.12.2014, p. 1026-1032.

Research output: Contribution to journalArticle

Roberts, JD, Dewland, T, Longoria, J, Fitzpatrick, AL, Ziv, E, Hu, D, Lin, J, Glidden, DV, Psaty, BM, Burchard, EG, Blackburn, EH, Olgin, JE, Heckbert, SR & Marcus, GM 2014, 'Telomere length and the risk of atrial fibrillation insights into the role of biological versus chronological aging', Circulation: Arrhythmia and Electrophysiology, vol. 7, no. 6, pp. 1026-1032. https://doi.org/10.1161/CIRCEP.114.001781
Roberts, Jason D. ; Dewland, Thomas ; Longoria, James ; Fitzpatrick, Annette L. ; Ziv, Elad ; Hu, Donglei ; Lin, Jue ; Glidden, David V. ; Psaty, Bruce M. ; Burchard, Esteban G. ; Blackburn, Elizabeth H. ; Olgin, Jeffrey E. ; Heckbert, Susan R. ; Marcus, Gregory M. / Telomere length and the risk of atrial fibrillation insights into the role of biological versus chronological aging. In: Circulation: Arrhythmia and Electrophysiology. 2014 ; Vol. 7, No. 6. pp. 1026-1032.
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AU - Dewland, Thomas

AU - Longoria, James

AU - Fitzpatrick, Annette L.

AU - Ziv, Elad

AU - Hu, Donglei

AU - Lin, Jue

AU - Glidden, David V.

AU - Psaty, Bruce M.

AU - Burchard, Esteban G.

AU - Blackburn, Elizabeth H.

AU - Olgin, Jeffrey E.

AU - Heckbert, Susan R.

AU - Marcus, Gregory M.

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