Tear film, pharmacology of eyedrops, and toxicity

William Mathers, H. D. Cavanagh

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Objective methods are now available to more effectively evaluate the dry eye and the surface toxicity associated with ophthalmic preparations and contact lens wear. Tear osmolarity, ocular surface evaporation, fluorophotometric tear flow, and meibomian gland imaging can be used to assess the dry eye state. Studies have demonstrated that evaporation plays a greater role in most dry eye conditions than was previously estimated. Tear protein analysis for lactate dehydrogenase, malate dehydrogenase, and albumin levels can be used as markers for epithelial cell toxicity and can be combined with tandem scanning confocal microscopy of the epithelium to demonstrate and quantify changes in epithelium morphology and function due to contact lens wear and ophthalmic medications.

Original languageEnglish (US)
Pages (from-to)13-18
Number of pages6
JournalCurrent Opinion in Ophthalmology
Volume5
Issue number4
StatePublished - 1994
Externally publishedYes

Fingerprint

Ophthalmic Solutions
Tears
Pharmacology
Contact Lenses
Epithelium
Meibomian Glands
Malate Dehydrogenase
Crystalline Lens
L-Lactate Dehydrogenase
Confocal Microscopy
Osmolar Concentration
Albumins
Epithelial Cells

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Tear film, pharmacology of eyedrops, and toxicity. / Mathers, William; Cavanagh, H. D.

In: Current Opinion in Ophthalmology, Vol. 5, No. 4, 1994, p. 13-18.

Research output: Contribution to journalArticle

@article{3fe435e939da49d785a3f57bf86932f3,
title = "Tear film, pharmacology of eyedrops, and toxicity",
abstract = "Objective methods are now available to more effectively evaluate the dry eye and the surface toxicity associated with ophthalmic preparations and contact lens wear. Tear osmolarity, ocular surface evaporation, fluorophotometric tear flow, and meibomian gland imaging can be used to assess the dry eye state. Studies have demonstrated that evaporation plays a greater role in most dry eye conditions than was previously estimated. Tear protein analysis for lactate dehydrogenase, malate dehydrogenase, and albumin levels can be used as markers for epithelial cell toxicity and can be combined with tandem scanning confocal microscopy of the epithelium to demonstrate and quantify changes in epithelium morphology and function due to contact lens wear and ophthalmic medications.",
author = "William Mathers and Cavanagh, {H. D.}",
year = "1994",
language = "English (US)",
volume = "5",
pages = "13--18",
journal = "Current Opinion in Ophthalmology",
issn = "1040-8738",
publisher = "Lippincott Williams and Wilkins",
number = "4",

}

TY - JOUR

T1 - Tear film, pharmacology of eyedrops, and toxicity

AU - Mathers, William

AU - Cavanagh, H. D.

PY - 1994

Y1 - 1994

N2 - Objective methods are now available to more effectively evaluate the dry eye and the surface toxicity associated with ophthalmic preparations and contact lens wear. Tear osmolarity, ocular surface evaporation, fluorophotometric tear flow, and meibomian gland imaging can be used to assess the dry eye state. Studies have demonstrated that evaporation plays a greater role in most dry eye conditions than was previously estimated. Tear protein analysis for lactate dehydrogenase, malate dehydrogenase, and albumin levels can be used as markers for epithelial cell toxicity and can be combined with tandem scanning confocal microscopy of the epithelium to demonstrate and quantify changes in epithelium morphology and function due to contact lens wear and ophthalmic medications.

AB - Objective methods are now available to more effectively evaluate the dry eye and the surface toxicity associated with ophthalmic preparations and contact lens wear. Tear osmolarity, ocular surface evaporation, fluorophotometric tear flow, and meibomian gland imaging can be used to assess the dry eye state. Studies have demonstrated that evaporation plays a greater role in most dry eye conditions than was previously estimated. Tear protein analysis for lactate dehydrogenase, malate dehydrogenase, and albumin levels can be used as markers for epithelial cell toxicity and can be combined with tandem scanning confocal microscopy of the epithelium to demonstrate and quantify changes in epithelium morphology and function due to contact lens wear and ophthalmic medications.

UR - http://www.scopus.com/inward/record.url?scp=0028124197&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0028124197&partnerID=8YFLogxK

M3 - Article

VL - 5

SP - 13

EP - 18

JO - Current Opinion in Ophthalmology

JF - Current Opinion in Ophthalmology

SN - 1040-8738

IS - 4

ER -