Tales of regeneration in zebrafish

Kenneth D. Poss, Mark T. Keating, Alex Nechiporuk

Research output: Contribution to journalReview article

288 Scopus citations

Abstract

Complex tissue regeneration involves exquisitely coordinated proliferation and patterning of adult cells after severe injury or amputation. Certain lower vertebrates such as urodele amphibians and teleost fish have a greater capacity for regeneration than mammals. However, little is known about molecular mechanisms of regeneration, and cellular mechanisms are incompletely defined. To address this deficiency, we and others have focused on the zebrafish model system. Several helpful tools and reagents are available for use with zebrafish, including the potential for genetic approaches to regeneration. Recent studies have shed light on the remarkable ability of zebrafish to regenerate fins.

Original languageEnglish (US)
Pages (from-to)202-210
Number of pages9
JournalDevelopmental Dynamics
Volume226
Issue number2
DOIs
StatePublished - Feb 1 2003

Keywords

  • Blastema
  • Fgf
  • Fin
  • Limb
  • Regeneration
  • Shh
  • Wound healing
  • Zebrafish

ASJC Scopus subject areas

  • Developmental Biology

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