Taking out TB - lysosomal trafficking and mycobactericidal ubiquitin-derived peptides

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Tuberculosis remains a significant global health concern. The hallmark of Mycobacterium tuberculosis pathogenicity is its ability to infect resting macrophages and establish an intracellular niche. Activated and autophagic macrophages control mycobacterial infections through bactericidal mechanisms ranging from reactive oxygen and nitrogen intermediates to the delivery of the bacterium to the acidified, hydrolytically active lysosome. The mycobactericidal activity of the lysosome is due in part to the action of ubiquitin-derived peptides (Ub-peptides). In this review we discuss the trafficking events that result in delivery M. tuberculosis to the lysosome, the source and lysosomal generation of Ub-peptides and their role in macrophage control of M. tuberculosis infection.

Original languageEnglish (US)
JournalFrontiers in Microbiology
Volume2
Issue numberJAN
DOIs
StatePublished - 2011

Fingerprint

Ubiquitin
Lysosomes
Mycobacterium tuberculosis
Macrophages
Peptides
Mycobacterium Infections
Infection Control
Virulence
Tuberculosis
Nitrogen
Oxygen
Bacteria

Keywords

  • Autophagy
  • Lysosome
  • Mycobacterium
  • Tuberculosis
  • Ub-peptides
  • Ubiquitin

ASJC Scopus subject areas

  • Microbiology
  • Microbiology (medical)

Cite this

Taking out TB - lysosomal trafficking and mycobactericidal ubiquitin-derived peptides. / Purdy, Georgiana.

In: Frontiers in Microbiology, Vol. 2, No. JAN, 2011.

Research output: Contribution to journalArticle

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