Tacrolimus pharmacokinetics in Hispanic children after kidney transplantation

G. Cherala, M. Y. Munar, A. Naher, Amira Al-Uzri

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

Ethnic differences in drug pharmacokinetics are well recognized including that for tacrolimus (TAC) in adult subjects. However, similar knowledge among pediatric populations is missing. Our limited retrospective study compares steady-state pharmacokinetics of TAC in Hispanic versus non-Hispanic children. Serial blood samples were collected and whole blood concentrations of TAC were measured using radioimmunoassay. Compared with non-Hispanic children, Hispanic children had lower measures of drug exposure (maximum drug concentration [C max] and area under the drug concentration-time curve [AUC 0-∞]), higher volume of distribution, and faster clearance. Interestingly, only in Hispanic children, significant correlations were found between body weight and clearance, age and volume of distribution, and Schwartz estimated glomerular filtration rate and half-life. In conclusion, our study suggests that ethnic differences exist between Hispanic and non-Hispanic children in TAC PK, and based on our preliminary findings, either a higher or more frequent TAC dosing may be required for effective immunosuppression therapy in Hispanic children.

Original languageEnglish (US)
Pages (from-to)3708-3712
Number of pages5
JournalTransplantation Proceedings
Volume43
Issue number10
DOIs
Publication statusPublished - Dec 2011

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ASJC Scopus subject areas

  • Surgery
  • Transplantation

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