T cell lines selected with synthetic peptides are highly encephalitogenic in SJL/J mice

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

T cell lines were selected from basic protein (BP)-immunized SJL/J mice using synthetic peptides encompassing the major SJL/J encephalitogenic determinant. Synthetic peptide-derived T cell lines proliferated in response to BP, the 89-169 peptides fragment of BP and the synthetic peptides, pM87-99, pM90-99 and pM91-99. These lines transferred a demyelinating and chronic relapsing form of experimental autoimmune encephalomyelitis (EAE) into naive mice, and EAE induced by synthetic peptide-derived lines was more severe than that induced by whole BP-derived lines. This study demonstrates that T cell lines selected with synthetic peptides are encephalitogenic in SJL/J mice and offers an improved means for selecting SJL/J encephalitogenic T cell lines.

Original languageEnglish (US)
Pages (from-to)255-260
Number of pages6
JournalJournal of Neuroimmunology
Volume22
Issue number3
DOIs
StatePublished - May 1989

Keywords

  • (SJL/J mouse)
  • Basic protein-specific T cell line
  • Encephalitogenic epitope
  • Experimental autoimmune encephalomyelitis

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Neurology
  • Clinical Neurology

Fingerprint Dive into the research topics of 'T cell lines selected with synthetic peptides are highly encephalitogenic in SJL/J mice'. Together they form a unique fingerprint.

  • Cite this