Systemic immunosuppressive agents were used by 85.7% and 78.5% of patients, respectively. Over time, patients with ANCA-positive vasculitis experienced 2.75-fold higher mortality than other patients with inflammatory eye disease. Ocular disease in patients with ANCA-positive vasculitis

Angela S. Watkins, John H. Kempen, Dongseok Choi, Teresa L. Liesegang, S. S. Pujari, Craig Newcomb, Robert B. Nussenblatt, James (Jim) Rosenbaum, Jennifer E. Thorne, C. Stephen Foster, Douglas A. Jabs, Grace A. Levy-Clarke, Eric Suhler, Justine R. Smith

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

Anti-neutrophil cytoplasmic antibody (ANCA)-positive vasculitis-the term recently applied to Wegener's granulomatosis-is a rare multi-system inflammation characterized by necrotizing granulomas and vasculitis. We investigated the ocular manifestations of this disease in a group of patients drawn from five inflammatory eye disease clinics across the United States. Of 8,562 persons with ocular inflammation, 59 individuals were diagnosed with ANCA-positive vasculitis; 35 males and 21 females, aged 16 to 96 years, were included in this study. Ocular diagnoses were scleritis (75.0%), uveitis (17.9%), and other ocular inflammatory conditions (33.9%) including peripheral ulcer-ative keratitis and orbital pseudotumor. Mean duration of ocular disease was 4.6 years. Oral corticosteroids and other

Original languageEnglish (US)
Pages (from-to)12-19
Number of pages8
JournalJournal of Ocular Biology, Diseases, and Informatics
Volume3
Issue number1
DOIs
StatePublished - Mar 2010

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Antineutrophil Cytoplasmic Antibodies
Eye Diseases
Immunosuppressive Agents
Vasculitis
Mortality
Eye Manifestations
Orbital Pseudotumor
Scleritis
Inflammation
Granulomatosis with Polyangiitis
Keratitis
Uveitis
Granuloma
Ulcer
Adrenal Cortex Hormones

Keywords

  • ANCA-positive vasculitis
  • Eye
  • Scleritis
  • Wegener's granulomatosis

ASJC Scopus subject areas

  • Ophthalmology
  • Genetics

Cite this

Systemic immunosuppressive agents were used by 85.7% and 78.5% of patients, respectively. Over time, patients with ANCA-positive vasculitis experienced 2.75-fold higher mortality than other patients with inflammatory eye disease. Ocular disease in patients with ANCA-positive vasculitis. / Watkins, Angela S.; Kempen, John H.; Choi, Dongseok; Liesegang, Teresa L.; Pujari, S. S.; Newcomb, Craig; Nussenblatt, Robert B.; Rosenbaum, James (Jim); Thorne, Jennifer E.; Foster, C. Stephen; Jabs, Douglas A.; Levy-Clarke, Grace A.; Suhler, Eric; Smith, Justine R.

In: Journal of Ocular Biology, Diseases, and Informatics, Vol. 3, No. 1, 03.2010, p. 12-19.

Research output: Contribution to journalArticle

Watkins, Angela S. ; Kempen, John H. ; Choi, Dongseok ; Liesegang, Teresa L. ; Pujari, S. S. ; Newcomb, Craig ; Nussenblatt, Robert B. ; Rosenbaum, James (Jim) ; Thorne, Jennifer E. ; Foster, C. Stephen ; Jabs, Douglas A. ; Levy-Clarke, Grace A. ; Suhler, Eric ; Smith, Justine R. / Systemic immunosuppressive agents were used by 85.7% and 78.5% of patients, respectively. Over time, patients with ANCA-positive vasculitis experienced 2.75-fold higher mortality than other patients with inflammatory eye disease. Ocular disease in patients with ANCA-positive vasculitis. In: Journal of Ocular Biology, Diseases, and Informatics. 2010 ; Vol. 3, No. 1. pp. 12-19.
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