Systematic review and meta-analysis of the literature regarding the diagnosis of sleep apnea

Susan D. Ross, Iris A. Sheinhait, Katherine J. Harrison, Marion Kvasz, Janet E. Connelly, Steven Shea, I. Elaine Allen

Research output: Contribution to journalArticle

107 Citations (Scopus)

Abstract

To establish the evidence base for the diagnosis of sleep apnea (SA) in adult patients, a systematic review of the literature from 1980 through November 1, 1997 was performed. Diagnostic studies were included if they reported results of any test to establish or support a diagnosis of SA, in comparison to a diagnosis from a full polysomnogram (PSG). Test results were meta-analyzed using fixed effects models and summary receiver operating characteristic curves (ROCs) to examine consistency of tests within and between diagnostics vs. the 'gold standard' of PSG. From a total of 937 studies, 249 fit the broad eligibility criteria for inclusion in the clinical trial database and its data were extracted from these reports; useable data for statistical analyses were reported in 71 studies (7,572 patients). The sensitivity and specificity of partial channel and partial time PSGs appeared most promising as replacements for full PSG in patients suspected of obstructive SA. Clinical prediction rules (multivariate models) were also promising. Studies of portable sleep monitors, radiologic or morphologic features, and focused questionnaires were too heterogeneous to be meta- analyzed. In general, the diversity of study designs and objectives were very high and the methodological rigor of these studies as assessments of diagnostic tests was very low. Thus, we are still not in a position to recommend standardization of diagnostic methodology for sleep apnea. Instead, our recommendations for future research include standardization of terms and diagnostic criteria, and consistently reported statistics to enhance the utility of this literature.

Original languageEnglish (US)
Pages (from-to)519-532
Number of pages14
JournalSleep
Volume23
Issue number4
StatePublished - Jun 15 2000
Externally publishedYes

Fingerprint

Sleep Apnea Syndromes
Meta-Analysis
Statistical Data Interpretation
Decision Support Techniques
Obstructive Sleep Apnea
Routine Diagnostic Tests
ROC Curve
Sleep
Clinical Trials
Databases
Sensitivity and Specificity

Keywords

  • Diagnosis
  • Meta-analysis
  • Polysomnogram
  • Sleep apnea
  • Systematic review

ASJC Scopus subject areas

  • Physiology

Cite this

Ross, S. D., Sheinhait, I. A., Harrison, K. J., Kvasz, M., Connelly, J. E., Shea, S., & Allen, I. E. (2000). Systematic review and meta-analysis of the literature regarding the diagnosis of sleep apnea. Sleep, 23(4), 519-532.

Systematic review and meta-analysis of the literature regarding the diagnosis of sleep apnea. / Ross, Susan D.; Sheinhait, Iris A.; Harrison, Katherine J.; Kvasz, Marion; Connelly, Janet E.; Shea, Steven; Allen, I. Elaine.

In: Sleep, Vol. 23, No. 4, 15.06.2000, p. 519-532.

Research output: Contribution to journalArticle

Ross, SD, Sheinhait, IA, Harrison, KJ, Kvasz, M, Connelly, JE, Shea, S & Allen, IE 2000, 'Systematic review and meta-analysis of the literature regarding the diagnosis of sleep apnea', Sleep, vol. 23, no. 4, pp. 519-532.
Ross SD, Sheinhait IA, Harrison KJ, Kvasz M, Connelly JE, Shea S et al. Systematic review and meta-analysis of the literature regarding the diagnosis of sleep apnea. Sleep. 2000 Jun 15;23(4):519-532.
Ross, Susan D. ; Sheinhait, Iris A. ; Harrison, Katherine J. ; Kvasz, Marion ; Connelly, Janet E. ; Shea, Steven ; Allen, I. Elaine. / Systematic review and meta-analysis of the literature regarding the diagnosis of sleep apnea. In: Sleep. 2000 ; Vol. 23, No. 4. pp. 519-532.
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