Synthesis and characterization of lipid-polymer hybrid nanoparticles with ph-triggered poly(ethylene glycol) shedding

Corbin Clawson, Linh Ton, Santosh Aryal, Victoria Fu, Sadik Esener, Liangfang Zhang

Research output: Contribution to journalArticle

59 Scopus citations

Abstract

Novel lipid-polymer hybrid nanoparticles are designed with a poly(ethylene glycol) (PEG) coating that is shed in response to a low pH trigger. This allows the nanoparticles to be stable during systemic circulation and at neutral pH, but destabilize and fuse with lipid membranes in acidic environments. The hybrid nanoparticles consist of a poly(lactic-co-glycolic acid) core with a lipid and lipid-PEG monolayer shell. To make the hybrid nanoparticles pH sensitive, a lipid-(succinate)-mPEG conjugate is synthesized to provide a hydrolyzable PEG stealth layer that is shed off the particle surface at low pH. The pH-sensitivity of the nanoparticles is tunable using the molar concentration of the lipid-(succinate)-mPEG incorporated in the lipid shell of the particles. Possible uses of these pH-sensitive nanoparticles include aggregating in acidic tumor microenvironments, escaping acidified endosomes, or aggregating in deep lung tissue for improved inhalation administration.

Original languageEnglish (US)
Pages (from-to)10556-10561
Number of pages6
JournalLangmuir
Volume27
Issue number17
DOIs
StatePublished - Sep 6 2011

ASJC Scopus subject areas

  • Materials Science(all)
  • Condensed Matter Physics
  • Surfaces and Interfaces
  • Spectroscopy
  • Electrochemistry

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