Synaptic membrane structure as a determinant of CNS drug actions and interactions

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

The purpose of this communication is to review the progress in determining the relationships between synaptic membrane structure and mechanisms of drug action. As far as possible, the focus of the discussion will be on CNS synaptic membrane constituents. However, occasionally it will be necessary to draw on information from peripheral neurons, neural cell cultures, and, in some cases, from non-neuronal tissues. Finally, the emphasis of this review will be on the synaptic membrane lipids. Given the difficulty in isolating, purifying and assigning a function to synaptic membrane proteins, it seems likely that our most productive focus in determining structural-functional relationships will be on the membrane lipids. The data reviewed here illustrate the variety of roles synaptic membrane lipids can play in the mechanisms of neurotransmitter and drug action. In some cases, the lipids may be part of the receptor complex and directly participate in the physiological or pharmacological effect. In other cases, the lipids may serve a more regulatory or modulatory role. However, the overall importance of the lipid effects cannot be denied and future studies will only serve to expand upon and confirm this importance.

Original languageEnglish (US)
Pages (from-to)155-194
Number of pages40
JournalReviews on Drug Metabolism and Drug Interactions
Volume3
Issue number3
StatePublished - 1980
Externally publishedYes

Fingerprint

Synaptic Membranes
Drug Interactions
Membrane Lipids
Lipids
Pharmaceutical Preparations
Neurotransmitter Agents
Membrane Proteins
Cell Culture Techniques
Pharmacology
Neurons

ASJC Scopus subject areas

  • Pharmacology (medical)

Cite this

Synaptic membrane structure as a determinant of CNS drug actions and interactions. / Loh, H.; Hitzemann, Robert.

In: Reviews on Drug Metabolism and Drug Interactions, Vol. 3, No. 3, 1980, p. 155-194.

Research output: Contribution to journalArticle

@article{6a6948dd0a2d47ad86752267ae774b21,
title = "Synaptic membrane structure as a determinant of CNS drug actions and interactions",
abstract = "The purpose of this communication is to review the progress in determining the relationships between synaptic membrane structure and mechanisms of drug action. As far as possible, the focus of the discussion will be on CNS synaptic membrane constituents. However, occasionally it will be necessary to draw on information from peripheral neurons, neural cell cultures, and, in some cases, from non-neuronal tissues. Finally, the emphasis of this review will be on the synaptic membrane lipids. Given the difficulty in isolating, purifying and assigning a function to synaptic membrane proteins, it seems likely that our most productive focus in determining structural-functional relationships will be on the membrane lipids. The data reviewed here illustrate the variety of roles synaptic membrane lipids can play in the mechanisms of neurotransmitter and drug action. In some cases, the lipids may be part of the receptor complex and directly participate in the physiological or pharmacological effect. In other cases, the lipids may serve a more regulatory or modulatory role. However, the overall importance of the lipid effects cannot be denied and future studies will only serve to expand upon and confirm this importance.",
author = "H. Loh and Robert Hitzemann",
year = "1980",
language = "English (US)",
volume = "3",
pages = "155--194",
journal = "Drug Metabolism and Personalized Therapy",
issn = "2363-8907",
publisher = "Walter de Gruyter GmbH & Co. KG",
number = "3",

}

TY - JOUR

T1 - Synaptic membrane structure as a determinant of CNS drug actions and interactions

AU - Loh, H.

AU - Hitzemann, Robert

PY - 1980

Y1 - 1980

N2 - The purpose of this communication is to review the progress in determining the relationships between synaptic membrane structure and mechanisms of drug action. As far as possible, the focus of the discussion will be on CNS synaptic membrane constituents. However, occasionally it will be necessary to draw on information from peripheral neurons, neural cell cultures, and, in some cases, from non-neuronal tissues. Finally, the emphasis of this review will be on the synaptic membrane lipids. Given the difficulty in isolating, purifying and assigning a function to synaptic membrane proteins, it seems likely that our most productive focus in determining structural-functional relationships will be on the membrane lipids. The data reviewed here illustrate the variety of roles synaptic membrane lipids can play in the mechanisms of neurotransmitter and drug action. In some cases, the lipids may be part of the receptor complex and directly participate in the physiological or pharmacological effect. In other cases, the lipids may serve a more regulatory or modulatory role. However, the overall importance of the lipid effects cannot be denied and future studies will only serve to expand upon and confirm this importance.

AB - The purpose of this communication is to review the progress in determining the relationships between synaptic membrane structure and mechanisms of drug action. As far as possible, the focus of the discussion will be on CNS synaptic membrane constituents. However, occasionally it will be necessary to draw on information from peripheral neurons, neural cell cultures, and, in some cases, from non-neuronal tissues. Finally, the emphasis of this review will be on the synaptic membrane lipids. Given the difficulty in isolating, purifying and assigning a function to synaptic membrane proteins, it seems likely that our most productive focus in determining structural-functional relationships will be on the membrane lipids. The data reviewed here illustrate the variety of roles synaptic membrane lipids can play in the mechanisms of neurotransmitter and drug action. In some cases, the lipids may be part of the receptor complex and directly participate in the physiological or pharmacological effect. In other cases, the lipids may serve a more regulatory or modulatory role. However, the overall importance of the lipid effects cannot be denied and future studies will only serve to expand upon and confirm this importance.

UR - http://www.scopus.com/inward/record.url?scp=0019239746&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0019239746&partnerID=8YFLogxK

M3 - Article

AN - SCOPUS:0019239746

VL - 3

SP - 155

EP - 194

JO - Drug Metabolism and Personalized Therapy

JF - Drug Metabolism and Personalized Therapy

SN - 2363-8907

IS - 3

ER -