Synaptic desensitization of NMDA receptors by calcineurin

Gang Tong, Dawn Shepherd, Craig Jahr

Research output: Contribution to journalArticle

335 Citations (Scopus)

Abstract

Desensitization is a phenomenon that is common to many ligand-gated ion channels but has been demonstrated only rarely with physiological stimulation. Numerous studies describe desensitization of the N-methyl-D-aspartate (NMDA) subtype of glutamate receptor by exogenous agonists, but whether synaptic stimulation causes desensitization has been unknown. Synaptic stimulation of NMDA receptors on rat hippocampal neurons resulted in desensitization that was prevented by intracellular 1,2-bis(o-aminophenoxy)ethane-N,N,N'N'-tetraacetic acid (BAPTA), adenosine-5'-O-(3-thiotriphosphate) (ATP-γ-S), or inhibitors of phosphatase 28 (calcineurin), but not by inhibitors of phosphatases 1 and 2A or of tyrosine phosphatases. Synaptic NMDA receptors may fluctuate between phosphorylated and dephosphorylated forms, depending on the rate of synaptic stimulation and the magnitude of the associated influx of calcium through NMDA receptors.

Original languageEnglish (US)
Pages (from-to)1510-1512
Number of pages3
JournalScience
Volume267
Issue number5203
StatePublished - Mar 10 1995

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Calcineurin
N-Methyl-D-Aspartate Receptors
Phosphoric Monoester Hydrolases
Ligand-Gated Ion Channels
Glutamate Receptors
N-Methylaspartate
Tyrosine
Adenosine Triphosphate
Calcium
Neurons
1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid

ASJC Scopus subject areas

  • General

Cite this

Tong, G., Shepherd, D., & Jahr, C. (1995). Synaptic desensitization of NMDA receptors by calcineurin. Science, 267(5203), 1510-1512.

Synaptic desensitization of NMDA receptors by calcineurin. / Tong, Gang; Shepherd, Dawn; Jahr, Craig.

In: Science, Vol. 267, No. 5203, 10.03.1995, p. 1510-1512.

Research output: Contribution to journalArticle

Tong, G, Shepherd, D & Jahr, C 1995, 'Synaptic desensitization of NMDA receptors by calcineurin', Science, vol. 267, no. 5203, pp. 1510-1512.
Tong G, Shepherd D, Jahr C. Synaptic desensitization of NMDA receptors by calcineurin. Science. 1995 Mar 10;267(5203):1510-1512.
Tong, Gang ; Shepherd, Dawn ; Jahr, Craig. / Synaptic desensitization of NMDA receptors by calcineurin. In: Science. 1995 ; Vol. 267, No. 5203. pp. 1510-1512.
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