Synaptic desensitization of NMDA receptors by calcineurin

Gang Tong, Dawn Shepherd, Craig E. Jahr

Research output: Contribution to journalArticle

338 Scopus citations

Abstract

Desensitization is a phenomenon that is common to many ligand-gated ion channels but has been demonstrated only rarely with physiological stimulation. Numerous studies describe desensitization of the N-methyl-D-aspartate (NMDA) subtype of glutamate receptor by exogenous agonists, but whether synaptic stimulation causes desensitization has been unknown. Synaptic stimulation of NMDA receptors on rat hippocampal neurons resulted in desensitization that was prevented by intracellular 1,2-bis(o-aminophenoxy)ethane-N,N,N'N'-tetraacetic acid (BAPTA), adenosine-5'-O-(3-thiotriphosphate) (ATP-γ-S), or inhibitors of phosphatase 28 (calcineurin), but not by inhibitors of phosphatases 1 and 2A or of tyrosine phosphatases. Synaptic NMDA receptors may fluctuate between phosphorylated and dephosphorylated forms, depending on the rate of synaptic stimulation and the magnitude of the associated influx of calcium through NMDA receptors.

Original languageEnglish (US)
Pages (from-to)1510-1512
Number of pages3
JournalScience
Volume267
Issue number5203
DOIs
StatePublished - Mar 10 1995

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    Tong, G., Shepherd, D., & Jahr, C. E. (1995). Synaptic desensitization of NMDA receptors by calcineurin. Science, 267(5203), 1510-1512. https://doi.org/10.1126/science.7878472