Synaptic activation of kainate receptors on hippocampal interneurons

Matthew Frerking, R. C. Malenka, R. A. Nicoll

Research output: Contribution to journalArticle

244 Citations (Scopus)

Abstract

Although kainate receptor activation has been known to evoke epileptiform activity, little is known about the role of kainate receptors in synaptic transmission. Here we report that kainate (KA) receptors are present on interneurons and, when activated, cause a large increase in the frequency of spontaneous inhibitory postsynaptic currents (IPSCs) driven by action potentials. Stimulation of excitatory afferents generates a pharmacologically identifiable synaptic current mediated by KA receptors in interneurons. This synaptic current is similar to that mediated by AMPA receptors in its response to short stimulus trains, current-voltage relations and coefficient of variation, but it is much smaller in peak amplitude and much slower. KA application also considerably depresses evoked IPSCs. This depression seems to be in large part an indirect consequence of the repetitive firing evoked by the activation of the interneuronal somatic/dendritic KA receptors.

Original languageEnglish (US)
Pages (from-to)479-486
Number of pages8
JournalMolecular Cell
Volume1
Issue number6
StatePublished - 1998
Externally publishedYes

Fingerprint

Kainic Acid Receptors
Interneurons
Inhibitory Postsynaptic Potentials
AMPA Receptors
Kainic Acid
Synaptic Transmission
Action Potentials

ASJC Scopus subject areas

  • Molecular Biology

Cite this

Frerking, M., Malenka, R. C., & Nicoll, R. A. (1998). Synaptic activation of kainate receptors on hippocampal interneurons. Molecular Cell, 1(6), 479-486.

Synaptic activation of kainate receptors on hippocampal interneurons. / Frerking, Matthew; Malenka, R. C.; Nicoll, R. A.

In: Molecular Cell, Vol. 1, No. 6, 1998, p. 479-486.

Research output: Contribution to journalArticle

Frerking, M, Malenka, RC & Nicoll, RA 1998, 'Synaptic activation of kainate receptors on hippocampal interneurons', Molecular Cell, vol. 1, no. 6, pp. 479-486.
Frerking M, Malenka RC, Nicoll RA. Synaptic activation of kainate receptors on hippocampal interneurons. Molecular Cell. 1998;1(6):479-486.
Frerking, Matthew ; Malenka, R. C. ; Nicoll, R. A. / Synaptic activation of kainate receptors on hippocampal interneurons. In: Molecular Cell. 1998 ; Vol. 1, No. 6. pp. 479-486.
@article{bf00ee830e0446f1b7a610e30e98f487,
title = "Synaptic activation of kainate receptors on hippocampal interneurons",
abstract = "Although kainate receptor activation has been known to evoke epileptiform activity, little is known about the role of kainate receptors in synaptic transmission. Here we report that kainate (KA) receptors are present on interneurons and, when activated, cause a large increase in the frequency of spontaneous inhibitory postsynaptic currents (IPSCs) driven by action potentials. Stimulation of excitatory afferents generates a pharmacologically identifiable synaptic current mediated by KA receptors in interneurons. This synaptic current is similar to that mediated by AMPA receptors in its response to short stimulus trains, current-voltage relations and coefficient of variation, but it is much smaller in peak amplitude and much slower. KA application also considerably depresses evoked IPSCs. This depression seems to be in large part an indirect consequence of the repetitive firing evoked by the activation of the interneuronal somatic/dendritic KA receptors.",
author = "Matthew Frerking and Malenka, {R. C.} and Nicoll, {R. A.}",
year = "1998",
language = "English (US)",
volume = "1",
pages = "479--486",
journal = "Molecular Cell",
issn = "1097-2765",
publisher = "Cell Press",
number = "6",

}

TY - JOUR

T1 - Synaptic activation of kainate receptors on hippocampal interneurons

AU - Frerking, Matthew

AU - Malenka, R. C.

AU - Nicoll, R. A.

PY - 1998

Y1 - 1998

N2 - Although kainate receptor activation has been known to evoke epileptiform activity, little is known about the role of kainate receptors in synaptic transmission. Here we report that kainate (KA) receptors are present on interneurons and, when activated, cause a large increase in the frequency of spontaneous inhibitory postsynaptic currents (IPSCs) driven by action potentials. Stimulation of excitatory afferents generates a pharmacologically identifiable synaptic current mediated by KA receptors in interneurons. This synaptic current is similar to that mediated by AMPA receptors in its response to short stimulus trains, current-voltage relations and coefficient of variation, but it is much smaller in peak amplitude and much slower. KA application also considerably depresses evoked IPSCs. This depression seems to be in large part an indirect consequence of the repetitive firing evoked by the activation of the interneuronal somatic/dendritic KA receptors.

AB - Although kainate receptor activation has been known to evoke epileptiform activity, little is known about the role of kainate receptors in synaptic transmission. Here we report that kainate (KA) receptors are present on interneurons and, when activated, cause a large increase in the frequency of spontaneous inhibitory postsynaptic currents (IPSCs) driven by action potentials. Stimulation of excitatory afferents generates a pharmacologically identifiable synaptic current mediated by KA receptors in interneurons. This synaptic current is similar to that mediated by AMPA receptors in its response to short stimulus trains, current-voltage relations and coefficient of variation, but it is much smaller in peak amplitude and much slower. KA application also considerably depresses evoked IPSCs. This depression seems to be in large part an indirect consequence of the repetitive firing evoked by the activation of the interneuronal somatic/dendritic KA receptors.

UR - http://www.scopus.com/inward/record.url?scp=33644677754&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33644677754&partnerID=8YFLogxK

M3 - Article

VL - 1

SP - 479

EP - 486

JO - Molecular Cell

JF - Molecular Cell

SN - 1097-2765

IS - 6

ER -