Susceptibility weighted imaging: Neuropsychologic outcome and pediatric head injury

Talin Babikian, M. Catherin Freier, Karen A. Tong, Joshua Nickerson, Christopher J. Wall, Barbara A. Holshouser, Todd Burley, Matt L. Riggs, Stephen Ashwal

Research output: Contribution to journalArticle

121 Citations (Scopus)

Abstract

Traumatic brain injury is among the most frequent pediatric neurologic disorders in the United States, affecting multiple aspects of neuropsychologic functioning. This study assessed the efficacy of susceptibility weighted imaging as a predictor of long-term neuropsychologic functioning after pediatric brain injury compared with magnetic resonance spectroscopic imaging. Susceptibility weighted imaging is a relatively new method that is considered superior to traditional magnetic resonance imaging sequences for detecting hemorrhagic diffuse axonal injury. In this study, imaging and spectroscopy were acquired 6 ± 4 days after injury. Measures of neuropsychologic functioning were administered to 18 children and adolescents 1-4 years post injury. Negative correlations between lesion number and volume with neuropsychologic functioning were demonstrated. Lesion volume explained over 32% of the variance in cognitive performance, explaining at least an additional 20% beyond injury severity and age at injury alone and 19% beyond magnetic resonance spectroscopic metabolite variables. Exploratory analyses resulted in notable trends, with lesions in deeper brain regions more strongly associated with poorer neuropsychologic performance. Improved detection of the extent of diffuse axonal injury following a brain injury will allow for a better understanding of its association with long-term outcome, which in turn can improve prognostic efficacy for effective treatment planning.

Original languageEnglish (US)
Pages (from-to)184-194
Number of pages11
JournalPediatric Neurology
Volume33
Issue number3
DOIs
StatePublished - Jan 1 2005
Externally publishedYes

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Craniocerebral Trauma
Diffuse Axonal Injury
Pediatrics
Wounds and Injuries
Brain Injuries
Magnetic Resonance Imaging
Nervous System Diseases
Spectrum Analysis
Magnetic Resonance Spectroscopy
Brain

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Neurology
  • Developmental Neuroscience
  • Clinical Neurology

Cite this

Babikian, T., Freier, M. C., Tong, K. A., Nickerson, J., Wall, C. J., Holshouser, B. A., ... Ashwal, S. (2005). Susceptibility weighted imaging: Neuropsychologic outcome and pediatric head injury. Pediatric Neurology, 33(3), 184-194. https://doi.org/10.1016/j.pediatrneurol.2005.03.015

Susceptibility weighted imaging : Neuropsychologic outcome and pediatric head injury. / Babikian, Talin; Freier, M. Catherin; Tong, Karen A.; Nickerson, Joshua; Wall, Christopher J.; Holshouser, Barbara A.; Burley, Todd; Riggs, Matt L.; Ashwal, Stephen.

In: Pediatric Neurology, Vol. 33, No. 3, 01.01.2005, p. 184-194.

Research output: Contribution to journalArticle

Babikian, T, Freier, MC, Tong, KA, Nickerson, J, Wall, CJ, Holshouser, BA, Burley, T, Riggs, ML & Ashwal, S 2005, 'Susceptibility weighted imaging: Neuropsychologic outcome and pediatric head injury', Pediatric Neurology, vol. 33, no. 3, pp. 184-194. https://doi.org/10.1016/j.pediatrneurol.2005.03.015
Babikian, Talin ; Freier, M. Catherin ; Tong, Karen A. ; Nickerson, Joshua ; Wall, Christopher J. ; Holshouser, Barbara A. ; Burley, Todd ; Riggs, Matt L. ; Ashwal, Stephen. / Susceptibility weighted imaging : Neuropsychologic outcome and pediatric head injury. In: Pediatric Neurology. 2005 ; Vol. 33, No. 3. pp. 184-194.
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