Susceptibility changes following bolus injections

M. S. Albert, W. Huang, J. H. Lee, C. S. Patlak, Charles Jr Springer

Research output: Contribution to journalArticle

56 Citations (Scopus)

Abstract

The general mechanism of bulk magnetic susceptibility (BMS) induced MRI contrast following a bolus injection is elaborated. Combining radiolabeled tracer data for the first pass of a bolus injection through the human brain with the application of Wiedemann's law allows us to calculate the lower limit for the time course of the vascular BMS following the injection of any contrast agent. Superparamagnetic iron oxide particles produce a much larger effect than any mononuclear Ln(III) chelate. We also calculate the BMS changes occurring after a dilution bolus injection (of isosmolal physiological saline) subsequent to a prior slow infusion of an intravascular contrast agent. This technique bears some resemblance to the increasingly important approach that exploits changes in only the level of blood oxygenation. The calculation indicates that contrast changes after the dilution bolus injection are smaller than those following Ln(III) agent injections but larger than those due to changes in blood oxygenation and suggests a way to possibly enhance the latter. We present an in vivo study demonstrating the dilution bolus injection technique in the mouse brain, and that features its rapid repeatability. Extrapolation of these results to the human, however, indicates that the saline volumes required for venous injections, except possibly for cardiac studies, would be prohibitively large. Smaller, catheter-delivered arterial bolus injections are feasible. We also suggest a method for using an agent bolus injection to measure the parenchymal BMS, and thus the iron content, of pathologically iron-loaded tissue.

Original languageEnglish (US)
Pages (from-to)700-708
Number of pages9
JournalMagnetic Resonance in Medicine
Volume29
Issue number5
StatePublished - 1993
Externally publishedYes

Fingerprint

Injections
Contrast Media
Iron
Brain
Blood Vessels
Catheters

Keywords

  • Bolus
  • Dilution
  • Nondiamagnetism
  • Susceptibility

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

Cite this

Albert, M. S., Huang, W., Lee, J. H., Patlak, C. S., & Springer, C. J. (1993). Susceptibility changes following bolus injections. Magnetic Resonance in Medicine, 29(5), 700-708.

Susceptibility changes following bolus injections. / Albert, M. S.; Huang, W.; Lee, J. H.; Patlak, C. S.; Springer, Charles Jr.

In: Magnetic Resonance in Medicine, Vol. 29, No. 5, 1993, p. 700-708.

Research output: Contribution to journalArticle

Albert, MS, Huang, W, Lee, JH, Patlak, CS & Springer, CJ 1993, 'Susceptibility changes following bolus injections', Magnetic Resonance in Medicine, vol. 29, no. 5, pp. 700-708.
Albert MS, Huang W, Lee JH, Patlak CS, Springer CJ. Susceptibility changes following bolus injections. Magnetic Resonance in Medicine. 1993;29(5):700-708.
Albert, M. S. ; Huang, W. ; Lee, J. H. ; Patlak, C. S. ; Springer, Charles Jr. / Susceptibility changes following bolus injections. In: Magnetic Resonance in Medicine. 1993 ; Vol. 29, No. 5. pp. 700-708.
@article{be69b196a7f64d28ae133d27b5823302,
title = "Susceptibility changes following bolus injections",
abstract = "The general mechanism of bulk magnetic susceptibility (BMS) induced MRI contrast following a bolus injection is elaborated. Combining radiolabeled tracer data for the first pass of a bolus injection through the human brain with the application of Wiedemann's law allows us to calculate the lower limit for the time course of the vascular BMS following the injection of any contrast agent. Superparamagnetic iron oxide particles produce a much larger effect than any mononuclear Ln(III) chelate. We also calculate the BMS changes occurring after a dilution bolus injection (of isosmolal physiological saline) subsequent to a prior slow infusion of an intravascular contrast agent. This technique bears some resemblance to the increasingly important approach that exploits changes in only the level of blood oxygenation. The calculation indicates that contrast changes after the dilution bolus injection are smaller than those following Ln(III) agent injections but larger than those due to changes in blood oxygenation and suggests a way to possibly enhance the latter. We present an in vivo study demonstrating the dilution bolus injection technique in the mouse brain, and that features its rapid repeatability. Extrapolation of these results to the human, however, indicates that the saline volumes required for venous injections, except possibly for cardiac studies, would be prohibitively large. Smaller, catheter-delivered arterial bolus injections are feasible. We also suggest a method for using an agent bolus injection to measure the parenchymal BMS, and thus the iron content, of pathologically iron-loaded tissue.",
keywords = "Bolus, Dilution, Nondiamagnetism, Susceptibility",
author = "Albert, {M. S.} and W. Huang and Lee, {J. H.} and Patlak, {C. S.} and Springer, {Charles Jr}",
year = "1993",
language = "English (US)",
volume = "29",
pages = "700--708",
journal = "Magnetic Resonance in Medicine",
issn = "0740-3194",
publisher = "John Wiley and Sons Inc.",
number = "5",

}

TY - JOUR

T1 - Susceptibility changes following bolus injections

AU - Albert, M. S.

AU - Huang, W.

AU - Lee, J. H.

AU - Patlak, C. S.

AU - Springer, Charles Jr

PY - 1993

Y1 - 1993

N2 - The general mechanism of bulk magnetic susceptibility (BMS) induced MRI contrast following a bolus injection is elaborated. Combining radiolabeled tracer data for the first pass of a bolus injection through the human brain with the application of Wiedemann's law allows us to calculate the lower limit for the time course of the vascular BMS following the injection of any contrast agent. Superparamagnetic iron oxide particles produce a much larger effect than any mononuclear Ln(III) chelate. We also calculate the BMS changes occurring after a dilution bolus injection (of isosmolal physiological saline) subsequent to a prior slow infusion of an intravascular contrast agent. This technique bears some resemblance to the increasingly important approach that exploits changes in only the level of blood oxygenation. The calculation indicates that contrast changes after the dilution bolus injection are smaller than those following Ln(III) agent injections but larger than those due to changes in blood oxygenation and suggests a way to possibly enhance the latter. We present an in vivo study demonstrating the dilution bolus injection technique in the mouse brain, and that features its rapid repeatability. Extrapolation of these results to the human, however, indicates that the saline volumes required for venous injections, except possibly for cardiac studies, would be prohibitively large. Smaller, catheter-delivered arterial bolus injections are feasible. We also suggest a method for using an agent bolus injection to measure the parenchymal BMS, and thus the iron content, of pathologically iron-loaded tissue.

AB - The general mechanism of bulk magnetic susceptibility (BMS) induced MRI contrast following a bolus injection is elaborated. Combining radiolabeled tracer data for the first pass of a bolus injection through the human brain with the application of Wiedemann's law allows us to calculate the lower limit for the time course of the vascular BMS following the injection of any contrast agent. Superparamagnetic iron oxide particles produce a much larger effect than any mononuclear Ln(III) chelate. We also calculate the BMS changes occurring after a dilution bolus injection (of isosmolal physiological saline) subsequent to a prior slow infusion of an intravascular contrast agent. This technique bears some resemblance to the increasingly important approach that exploits changes in only the level of blood oxygenation. The calculation indicates that contrast changes after the dilution bolus injection are smaller than those following Ln(III) agent injections but larger than those due to changes in blood oxygenation and suggests a way to possibly enhance the latter. We present an in vivo study demonstrating the dilution bolus injection technique in the mouse brain, and that features its rapid repeatability. Extrapolation of these results to the human, however, indicates that the saline volumes required for venous injections, except possibly for cardiac studies, would be prohibitively large. Smaller, catheter-delivered arterial bolus injections are feasible. We also suggest a method for using an agent bolus injection to measure the parenchymal BMS, and thus the iron content, of pathologically iron-loaded tissue.

KW - Bolus

KW - Dilution

KW - Nondiamagnetism

KW - Susceptibility

UR - http://www.scopus.com/inward/record.url?scp=0027212502&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0027212502&partnerID=8YFLogxK

M3 - Article

VL - 29

SP - 700

EP - 708

JO - Magnetic Resonance in Medicine

JF - Magnetic Resonance in Medicine

SN - 0740-3194

IS - 5

ER -