Suppression of melatonin secretion in some blind patients by exposure to bright light

Charles A. Czeisler, Theresa L. Shanahan, Elizabeth B. Klerman, Heinz Martens, Daniel J. Brotman, Jonathan Emens, Torsten Klein, Joseph F. Rizzo

Research output: Contribution to journalArticle

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Abstract

Background: Complete blindness generally results in the loss of synchronization of circadian rhythms to the 24-hour day and in recurrent insomnia. However, some blind patients maintain circadian entrainment. We undertook this study to determine whether some blind patients' eyes convey sufficient photic information to entrain the hypothalamic circadian pacemaker and suppress melatonin secretion, despite an apparently complete loss of visual function. Methods: We evaluated the input of light to the circadian pacemaker by testing the ability of bright light to decrease plasma melatonin concentrations in 11 blind patients with no conscious perception of light and in 6 normal subjects. We also evaluated circadian entrainment over time in the blind patients. Results: Plasma melatonin concentrations decreased during exposure to bright light in three sightless patients by an average (±SD) of 69±21 percent and in the normal subjects by an average of 66±15 percent. When two of these blind patients were tested with their eyes covered during exposure to light, plasma melatonin did not decrease. The three blind patients reported no difficulty sleeping and maintained apparent circadian entrainment to the 24-hour day. Plasma melatonin concentrations did not decrease during exposure to bright light in seven of the remaining blind patients; in the eighth, plasma melatonin was undetectable. These eight patients reported a history of insomnia, and in four the circadian temperature rhythm was not entrained to the 24-hour day. Conclusions: The visual subsystem that mediates the light-induced suppression of melatonin secretion remains functionally intact in some sightless patients. The absence of photic input to the circadian system thus constitutes a distinct form of blindness, associated with periodic insomnia, that afflicts most but not all patients with no conscious perception of light., Blindness afflicts more than 1 million Americans, 1/10 of whom have no conscious perception of light.1 The eyes of these blind persons are typically assumed to serve only a cosmetic function. However, besides mediating the perception of images, ocular input of light synchronizes the hypothalamic circadian pacemaker that regulates many physiologic and behavioral processes.2,3 Given the current understanding that light is the primary synchronizer of the circadian pacemaker, it is not surprising that in most totally blind persons the pacemaker is not synchronized with the 24-hour day. Instead, it oscillates around an intrinsic period of close to 24 hours…

Original languageEnglish (US)
Pages (from-to)6-11
Number of pages6
JournalNew England Journal of Medicine
Volume332
Issue number1
DOIs
StatePublished - Jan 5 1995
Externally publishedYes

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Melatonin
Light
Sleep Initiation and Maintenance Disorders
Blindness
Visually Impaired Persons
Circadian Rhythm
Aptitude
Cosmetics
Temperature

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Czeisler, C. A., Shanahan, T. L., Klerman, E. B., Martens, H., Brotman, D. J., Emens, J., ... Rizzo, J. F. (1995). Suppression of melatonin secretion in some blind patients by exposure to bright light. New England Journal of Medicine, 332(1), 6-11. https://doi.org/10.1056/NEJM199501053320102

Suppression of melatonin secretion in some blind patients by exposure to bright light. / Czeisler, Charles A.; Shanahan, Theresa L.; Klerman, Elizabeth B.; Martens, Heinz; Brotman, Daniel J.; Emens, Jonathan; Klein, Torsten; Rizzo, Joseph F.

In: New England Journal of Medicine, Vol. 332, No. 1, 05.01.1995, p. 6-11.

Research output: Contribution to journalArticle

Czeisler, CA, Shanahan, TL, Klerman, EB, Martens, H, Brotman, DJ, Emens, J, Klein, T & Rizzo, JF 1995, 'Suppression of melatonin secretion in some blind patients by exposure to bright light', New England Journal of Medicine, vol. 332, no. 1, pp. 6-11. https://doi.org/10.1056/NEJM199501053320102
Czeisler, Charles A. ; Shanahan, Theresa L. ; Klerman, Elizabeth B. ; Martens, Heinz ; Brotman, Daniel J. ; Emens, Jonathan ; Klein, Torsten ; Rizzo, Joseph F. / Suppression of melatonin secretion in some blind patients by exposure to bright light. In: New England Journal of Medicine. 1995 ; Vol. 332, No. 1. pp. 6-11.
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abstract = "Background: Complete blindness generally results in the loss of synchronization of circadian rhythms to the 24-hour day and in recurrent insomnia. However, some blind patients maintain circadian entrainment. We undertook this study to determine whether some blind patients' eyes convey sufficient photic information to entrain the hypothalamic circadian pacemaker and suppress melatonin secretion, despite an apparently complete loss of visual function. Methods: We evaluated the input of light to the circadian pacemaker by testing the ability of bright light to decrease plasma melatonin concentrations in 11 blind patients with no conscious perception of light and in 6 normal subjects. We also evaluated circadian entrainment over time in the blind patients. Results: Plasma melatonin concentrations decreased during exposure to bright light in three sightless patients by an average (±SD) of 69±21 percent and in the normal subjects by an average of 66±15 percent. When two of these blind patients were tested with their eyes covered during exposure to light, plasma melatonin did not decrease. The three blind patients reported no difficulty sleeping and maintained apparent circadian entrainment to the 24-hour day. Plasma melatonin concentrations did not decrease during exposure to bright light in seven of the remaining blind patients; in the eighth, plasma melatonin was undetectable. These eight patients reported a history of insomnia, and in four the circadian temperature rhythm was not entrained to the 24-hour day. Conclusions: The visual subsystem that mediates the light-induced suppression of melatonin secretion remains functionally intact in some sightless patients. The absence of photic input to the circadian system thus constitutes a distinct form of blindness, associated with periodic insomnia, that afflicts most but not all patients with no conscious perception of light., Blindness afflicts more than 1 million Americans, 1/10 of whom have no conscious perception of light.1 The eyes of these blind persons are typically assumed to serve only a cosmetic function. However, besides mediating the perception of images, ocular input of light synchronizes the hypothalamic circadian pacemaker that regulates many physiologic and behavioral processes.2,3 Given the current understanding that light is the primary synchronizer of the circadian pacemaker, it is not surprising that in most totally blind persons the pacemaker is not synchronized with the 24-hour day. Instead, it oscillates around an intrinsic period of close to 24 hours…",
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N2 - Background: Complete blindness generally results in the loss of synchronization of circadian rhythms to the 24-hour day and in recurrent insomnia. However, some blind patients maintain circadian entrainment. We undertook this study to determine whether some blind patients' eyes convey sufficient photic information to entrain the hypothalamic circadian pacemaker and suppress melatonin secretion, despite an apparently complete loss of visual function. Methods: We evaluated the input of light to the circadian pacemaker by testing the ability of bright light to decrease plasma melatonin concentrations in 11 blind patients with no conscious perception of light and in 6 normal subjects. We also evaluated circadian entrainment over time in the blind patients. Results: Plasma melatonin concentrations decreased during exposure to bright light in three sightless patients by an average (±SD) of 69±21 percent and in the normal subjects by an average of 66±15 percent. When two of these blind patients were tested with their eyes covered during exposure to light, plasma melatonin did not decrease. The three blind patients reported no difficulty sleeping and maintained apparent circadian entrainment to the 24-hour day. Plasma melatonin concentrations did not decrease during exposure to bright light in seven of the remaining blind patients; in the eighth, plasma melatonin was undetectable. These eight patients reported a history of insomnia, and in four the circadian temperature rhythm was not entrained to the 24-hour day. Conclusions: The visual subsystem that mediates the light-induced suppression of melatonin secretion remains functionally intact in some sightless patients. The absence of photic input to the circadian system thus constitutes a distinct form of blindness, associated with periodic insomnia, that afflicts most but not all patients with no conscious perception of light., Blindness afflicts more than 1 million Americans, 1/10 of whom have no conscious perception of light.1 The eyes of these blind persons are typically assumed to serve only a cosmetic function. However, besides mediating the perception of images, ocular input of light synchronizes the hypothalamic circadian pacemaker that regulates many physiologic and behavioral processes.2,3 Given the current understanding that light is the primary synchronizer of the circadian pacemaker, it is not surprising that in most totally blind persons the pacemaker is not synchronized with the 24-hour day. Instead, it oscillates around an intrinsic period of close to 24 hours…

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