Supersensitivity of anterior pituitary dopamine receptors involved in the inhibition of prolactin following destruction of the medial basal hypothalamus

Cecilia Cheung, R. I. Weiner

Research output: Contribution to journalArticle

47 Citations (Scopus)

Abstract

The medial basal hypothalamus of ovariectomized rats was destroyed using a modified Halasz knife. Large increases in prolactin secretion were observed 1 and 14 days following the lesions. Long- and short-term lesioned animals were anesthetized with chloral hydrate and treated with various doses of apomorphine (0.05, 0.2, 2, 5 mg/kg). Blood samples were obtained before and 10, 30 and 60 min after the injection. Both the 0.05 and 0.2 mg/kg doses caused significantly greater and longer lasting inhibition of prolactin in long term than in short term lesioned animals. Since the MBH was totally destroyed this study suggests that anterior pituitary dopamine receptors involved in the inhibition of prolactin secretion become supersensitive in long term lesioned rats.

Original languageEnglish (US)
Pages (from-to)914-917
Number of pages4
JournalEndocrinology
Volume99
Issue number3
StatePublished - 1976
Externally publishedYes

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Middle Hypothalamus
Dopamine Receptors
Prolactin
Chloral Hydrate
Apomorphine
Injections

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

Cite this

Supersensitivity of anterior pituitary dopamine receptors involved in the inhibition of prolactin following destruction of the medial basal hypothalamus. / Cheung, Cecilia; Weiner, R. I.

In: Endocrinology, Vol. 99, No. 3, 1976, p. 914-917.

Research output: Contribution to journalArticle

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