Summary of NIH medical-surgical emergency research roundtable held on April 30 to May 1, 2009

Amy H. Kaji, Roger J. Lewis, Tony Beavers-May, Robert Berg, Eileen Bulger, Charles Cairns, Clifton Callaway, Carlos A. Camargo, Joseph Carcillo, Roberta Debiasi, Tania Diaz, Francine Ducharme, Seth Glickman, Katherine Heilpern, Robert Hickey, Terry Vanden Hoek, Judd Hollander, Susan Janson, Gregory Jurkovich, Arthur Kellermann & 46 others Stephen Kingsmore, Jeffrey Kline, Nathan Kuppermann, Robert (Bob) Lowe, David McLario, Larry Nathanson, Graham Nichol, Andrew Peitzman, Lynne Richardson, Arthur Sanders, Manish Shah, Nathan Shapiro, Robert Silverman, Martin Than, Scott Wilber, Donald M. Yealy, Jeremy Brown, Nahid Akhyani, Guy Arcuri, Hugh Auchincloss, Sarah Dunsmore, Basil Eldadah, Rosemarie Filart, Giovanna Guerrero, Michael Handrigan, Steven Hirschfeld, Van Hubbard, Richard Hunt, Karen Huss, Daniel Kavanaugh, Paul Kimmel, Cheryl Kitt, Jeffrey Kopp, Jukka Korpela, Alice Mascette, Clement McDonald, Sarah Miers, Ryan Mutter, Jane Scott, Scott Somers, George Sopko, Betty Tai, Alkis Togias, Kishena Wadhwani, Kevin Wright, Debra Egan

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Study objective: In 2003, the Institute of Medicine Committee on the Future of Emergency Care in the United States Health System convened and identified a crisis in emergency care in the United States, including a need to enhance the research base for emergency care. As a result, the National Institutes of Health (NIH) formed an NIH Task Force on Research in Emergency Medicine to enhance NIH support for emergency care research. Members of the NIH Task Force and academic leaders in emergency care participated in 3 roundtable discussions to prioritize current opportunities for enhancing and conducting emergency care research. The objectives of these discussions were to identify key research questions essential to advancing the scientific underpinnings of emergency care and to discuss the barriers and best means to advance research by exploring the role of research networks and collaboration between the NIH and the emergency care community. Methods: The Medical-Surgical Research Roundtable was convened on April 30 to May 1, 2009. Before the roundtable, the emergency care domains to be discussed were selected and experts in each of the fields were invited to participate in the roundtable. Domain experts were asked to identify research priorities and challenges and separate them into mechanistic, translational, and clinical categories. After the conference, the lists were circulated among the participants and revised to reach a consensus. Results: Emergency care research is characterized by focus on the timing, sequence, and time sensitivity of disease processes and treatment effects. Rapidly identifying the phenotype and genotype of patients manifesting a specific disease process and the mechanistic reasons for heterogeneity in outcome are important challenges in emergency care research. Other research priorities include the need to elucidate the timing, sequence, and duration of causal molecular and cellular events involved in time-critical illnesses and injuries, and the development of treatments capable of halting or reversing them; the need for novel animal models; and the need to understand why there are regional differences in outcome for the same disease processes. Important barriers to emergency care research include a limited number of trained investigators and experienced mentors, limited research infrastructure and support, and regulatory hurdles. The science of emergency care may be advanced by facilitating the following: (1) training emergency care investigators with research training programs; (2) developing emergency care clinical research networks; (3) integrating emergency care research into Clinical and Translational Science Awards; (4) developing emergency carespecific initiatives within the existing structure of NIH institutes and centers; (5) involving emergency specialists in grant review and research advisory processes; (6) supporting learn-phase or small, clinical trials; and (7) performing research to address ethical and regulatory issues. Conclusion: Enhancing the research base supporting the care of medical and surgical emergencies will require progress in specific mechanistic, translational, and clinical domains; effective collaboration of academic investigators across traditional clinical and scientific boundaries; federal support of research in high-priority areas; and overcoming limitations in available infrastructure, research training, and access to patient populations.

Original languageEnglish (US)
Pages (from-to)522-537
Number of pages16
JournalAnnals of Emergency Medicine
Volume56
Issue number5
DOIs
StatePublished - Nov 2010

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National Institutes of Health (U.S.)
Emergency Medical Services
Emergencies
Research
Research Personnel
Advisory Committees
National Academies of Science, Engineering, and Medicine (U.S.) Health and Medicine Division
Mentors
Emergency Medicine
Organized Financing

ASJC Scopus subject areas

  • Emergency Medicine

Cite this

Kaji, A. H., Lewis, R. J., Beavers-May, T., Berg, R., Bulger, E., Cairns, C., ... Egan, D. (2010). Summary of NIH medical-surgical emergency research roundtable held on April 30 to May 1, 2009. Annals of Emergency Medicine, 56(5), 522-537. https://doi.org/10.1016/j.annemergmed.2010.03.014

Summary of NIH medical-surgical emergency research roundtable held on April 30 to May 1, 2009. / Kaji, Amy H.; Lewis, Roger J.; Beavers-May, Tony; Berg, Robert; Bulger, Eileen; Cairns, Charles; Callaway, Clifton; Camargo, Carlos A.; Carcillo, Joseph; Debiasi, Roberta; Diaz, Tania; Ducharme, Francine; Glickman, Seth; Heilpern, Katherine; Hickey, Robert; Hoek, Terry Vanden; Hollander, Judd; Janson, Susan; Jurkovich, Gregory; Kellermann, Arthur; Kingsmore, Stephen; Kline, Jeffrey; Kuppermann, Nathan; Lowe, Robert (Bob); McLario, David; Nathanson, Larry; Nichol, Graham; Peitzman, Andrew; Richardson, Lynne; Sanders, Arthur; Shah, Manish; Shapiro, Nathan; Silverman, Robert; Than, Martin; Wilber, Scott; Yealy, Donald M.; Brown, Jeremy; Akhyani, Nahid; Arcuri, Guy; Auchincloss, Hugh; Dunsmore, Sarah; Eldadah, Basil; Filart, Rosemarie; Guerrero, Giovanna; Handrigan, Michael; Hirschfeld, Steven; Hubbard, Van; Hunt, Richard; Huss, Karen; Kavanaugh, Daniel; Kimmel, Paul; Kitt, Cheryl; Kopp, Jeffrey; Korpela, Jukka; Mascette, Alice; McDonald, Clement; Miers, Sarah; Mutter, Ryan; Scott, Jane; Somers, Scott; Sopko, George; Tai, Betty; Togias, Alkis; Wadhwani, Kishena; Wright, Kevin; Egan, Debra.

In: Annals of Emergency Medicine, Vol. 56, No. 5, 11.2010, p. 522-537.

Research output: Contribution to journalArticle

Kaji, AH, Lewis, RJ, Beavers-May, T, Berg, R, Bulger, E, Cairns, C, Callaway, C, Camargo, CA, Carcillo, J, Debiasi, R, Diaz, T, Ducharme, F, Glickman, S, Heilpern, K, Hickey, R, Hoek, TV, Hollander, J, Janson, S, Jurkovich, G, Kellermann, A, Kingsmore, S, Kline, J, Kuppermann, N, Lowe, RB, McLario, D, Nathanson, L, Nichol, G, Peitzman, A, Richardson, L, Sanders, A, Shah, M, Shapiro, N, Silverman, R, Than, M, Wilber, S, Yealy, DM, Brown, J, Akhyani, N, Arcuri, G, Auchincloss, H, Dunsmore, S, Eldadah, B, Filart, R, Guerrero, G, Handrigan, M, Hirschfeld, S, Hubbard, V, Hunt, R, Huss, K, Kavanaugh, D, Kimmel, P, Kitt, C, Kopp, J, Korpela, J, Mascette, A, McDonald, C, Miers, S, Mutter, R, Scott, J, Somers, S, Sopko, G, Tai, B, Togias, A, Wadhwani, K, Wright, K & Egan, D 2010, 'Summary of NIH medical-surgical emergency research roundtable held on April 30 to May 1, 2009', Annals of Emergency Medicine, vol. 56, no. 5, pp. 522-537. https://doi.org/10.1016/j.annemergmed.2010.03.014
Kaji, Amy H. ; Lewis, Roger J. ; Beavers-May, Tony ; Berg, Robert ; Bulger, Eileen ; Cairns, Charles ; Callaway, Clifton ; Camargo, Carlos A. ; Carcillo, Joseph ; Debiasi, Roberta ; Diaz, Tania ; Ducharme, Francine ; Glickman, Seth ; Heilpern, Katherine ; Hickey, Robert ; Hoek, Terry Vanden ; Hollander, Judd ; Janson, Susan ; Jurkovich, Gregory ; Kellermann, Arthur ; Kingsmore, Stephen ; Kline, Jeffrey ; Kuppermann, Nathan ; Lowe, Robert (Bob) ; McLario, David ; Nathanson, Larry ; Nichol, Graham ; Peitzman, Andrew ; Richardson, Lynne ; Sanders, Arthur ; Shah, Manish ; Shapiro, Nathan ; Silverman, Robert ; Than, Martin ; Wilber, Scott ; Yealy, Donald M. ; Brown, Jeremy ; Akhyani, Nahid ; Arcuri, Guy ; Auchincloss, Hugh ; Dunsmore, Sarah ; Eldadah, Basil ; Filart, Rosemarie ; Guerrero, Giovanna ; Handrigan, Michael ; Hirschfeld, Steven ; Hubbard, Van ; Hunt, Richard ; Huss, Karen ; Kavanaugh, Daniel ; Kimmel, Paul ; Kitt, Cheryl ; Kopp, Jeffrey ; Korpela, Jukka ; Mascette, Alice ; McDonald, Clement ; Miers, Sarah ; Mutter, Ryan ; Scott, Jane ; Somers, Scott ; Sopko, George ; Tai, Betty ; Togias, Alkis ; Wadhwani, Kishena ; Wright, Kevin ; Egan, Debra. / Summary of NIH medical-surgical emergency research roundtable held on April 30 to May 1, 2009. In: Annals of Emergency Medicine. 2010 ; Vol. 56, No. 5. pp. 522-537.
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title = "Summary of NIH medical-surgical emergency research roundtable held on April 30 to May 1, 2009",
abstract = "Study objective: In 2003, the Institute of Medicine Committee on the Future of Emergency Care in the United States Health System convened and identified a crisis in emergency care in the United States, including a need to enhance the research base for emergency care. As a result, the National Institutes of Health (NIH) formed an NIH Task Force on Research in Emergency Medicine to enhance NIH support for emergency care research. Members of the NIH Task Force and academic leaders in emergency care participated in 3 roundtable discussions to prioritize current opportunities for enhancing and conducting emergency care research. The objectives of these discussions were to identify key research questions essential to advancing the scientific underpinnings of emergency care and to discuss the barriers and best means to advance research by exploring the role of research networks and collaboration between the NIH and the emergency care community. Methods: The Medical-Surgical Research Roundtable was convened on April 30 to May 1, 2009. Before the roundtable, the emergency care domains to be discussed were selected and experts in each of the fields were invited to participate in the roundtable. Domain experts were asked to identify research priorities and challenges and separate them into mechanistic, translational, and clinical categories. After the conference, the lists were circulated among the participants and revised to reach a consensus. Results: Emergency care research is characterized by focus on the timing, sequence, and time sensitivity of disease processes and treatment effects. Rapidly identifying the phenotype and genotype of patients manifesting a specific disease process and the mechanistic reasons for heterogeneity in outcome are important challenges in emergency care research. Other research priorities include the need to elucidate the timing, sequence, and duration of causal molecular and cellular events involved in time-critical illnesses and injuries, and the development of treatments capable of halting or reversing them; the need for novel animal models; and the need to understand why there are regional differences in outcome for the same disease processes. Important barriers to emergency care research include a limited number of trained investigators and experienced mentors, limited research infrastructure and support, and regulatory hurdles. The science of emergency care may be advanced by facilitating the following: (1) training emergency care investigators with research training programs; (2) developing emergency care clinical research networks; (3) integrating emergency care research into Clinical and Translational Science Awards; (4) developing emergency carespecific initiatives within the existing structure of NIH institutes and centers; (5) involving emergency specialists in grant review and research advisory processes; (6) supporting learn-phase or small, clinical trials; and (7) performing research to address ethical and regulatory issues. Conclusion: Enhancing the research base supporting the care of medical and surgical emergencies will require progress in specific mechanistic, translational, and clinical domains; effective collaboration of academic investigators across traditional clinical and scientific boundaries; federal support of research in high-priority areas; and overcoming limitations in available infrastructure, research training, and access to patient populations.",
author = "Kaji, {Amy H.} and Lewis, {Roger J.} and Tony Beavers-May and Robert Berg and Eileen Bulger and Charles Cairns and Clifton Callaway and Camargo, {Carlos A.} and Joseph Carcillo and Roberta Debiasi and Tania Diaz and Francine Ducharme and Seth Glickman and Katherine Heilpern and Robert Hickey and Hoek, {Terry Vanden} and Judd Hollander and Susan Janson and Gregory Jurkovich and Arthur Kellermann and Stephen Kingsmore and Jeffrey Kline and Nathan Kuppermann and Lowe, {Robert (Bob)} and David McLario and Larry Nathanson and Graham Nichol and Andrew Peitzman and Lynne Richardson and Arthur Sanders and Manish Shah and Nathan Shapiro and Robert Silverman and Martin Than and Scott Wilber and Yealy, {Donald M.} and Jeremy Brown and Nahid Akhyani and Guy Arcuri and Hugh Auchincloss and Sarah Dunsmore and Basil Eldadah and Rosemarie Filart and Giovanna Guerrero and Michael Handrigan and Steven Hirschfeld and Van Hubbard and Richard Hunt and Karen Huss and Daniel Kavanaugh and Paul Kimmel and Cheryl Kitt and Jeffrey Kopp and Jukka Korpela and Alice Mascette and Clement McDonald and Sarah Miers and Ryan Mutter and Jane Scott and Scott Somers and George Sopko and Betty Tai and Alkis Togias and Kishena Wadhwani and Kevin Wright and Debra Egan",
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T1 - Summary of NIH medical-surgical emergency research roundtable held on April 30 to May 1, 2009

AU - Kaji, Amy H.

AU - Lewis, Roger J.

AU - Beavers-May, Tony

AU - Berg, Robert

AU - Bulger, Eileen

AU - Cairns, Charles

AU - Callaway, Clifton

AU - Camargo, Carlos A.

AU - Carcillo, Joseph

AU - Debiasi, Roberta

AU - Diaz, Tania

AU - Ducharme, Francine

AU - Glickman, Seth

AU - Heilpern, Katherine

AU - Hickey, Robert

AU - Hoek, Terry Vanden

AU - Hollander, Judd

AU - Janson, Susan

AU - Jurkovich, Gregory

AU - Kellermann, Arthur

AU - Kingsmore, Stephen

AU - Kline, Jeffrey

AU - Kuppermann, Nathan

AU - Lowe, Robert (Bob)

AU - McLario, David

AU - Nathanson, Larry

AU - Nichol, Graham

AU - Peitzman, Andrew

AU - Richardson, Lynne

AU - Sanders, Arthur

AU - Shah, Manish

AU - Shapiro, Nathan

AU - Silverman, Robert

AU - Than, Martin

AU - Wilber, Scott

AU - Yealy, Donald M.

AU - Brown, Jeremy

AU - Akhyani, Nahid

AU - Arcuri, Guy

AU - Auchincloss, Hugh

AU - Dunsmore, Sarah

AU - Eldadah, Basil

AU - Filart, Rosemarie

AU - Guerrero, Giovanna

AU - Handrigan, Michael

AU - Hirschfeld, Steven

AU - Hubbard, Van

AU - Hunt, Richard

AU - Huss, Karen

AU - Kavanaugh, Daniel

AU - Kimmel, Paul

AU - Kitt, Cheryl

AU - Kopp, Jeffrey

AU - Korpela, Jukka

AU - Mascette, Alice

AU - McDonald, Clement

AU - Miers, Sarah

AU - Mutter, Ryan

AU - Scott, Jane

AU - Somers, Scott

AU - Sopko, George

AU - Tai, Betty

AU - Togias, Alkis

AU - Wadhwani, Kishena

AU - Wright, Kevin

AU - Egan, Debra

PY - 2010/11

Y1 - 2010/11

N2 - Study objective: In 2003, the Institute of Medicine Committee on the Future of Emergency Care in the United States Health System convened and identified a crisis in emergency care in the United States, including a need to enhance the research base for emergency care. As a result, the National Institutes of Health (NIH) formed an NIH Task Force on Research in Emergency Medicine to enhance NIH support for emergency care research. Members of the NIH Task Force and academic leaders in emergency care participated in 3 roundtable discussions to prioritize current opportunities for enhancing and conducting emergency care research. The objectives of these discussions were to identify key research questions essential to advancing the scientific underpinnings of emergency care and to discuss the barriers and best means to advance research by exploring the role of research networks and collaboration between the NIH and the emergency care community. Methods: The Medical-Surgical Research Roundtable was convened on April 30 to May 1, 2009. Before the roundtable, the emergency care domains to be discussed were selected and experts in each of the fields were invited to participate in the roundtable. Domain experts were asked to identify research priorities and challenges and separate them into mechanistic, translational, and clinical categories. After the conference, the lists were circulated among the participants and revised to reach a consensus. Results: Emergency care research is characterized by focus on the timing, sequence, and time sensitivity of disease processes and treatment effects. Rapidly identifying the phenotype and genotype of patients manifesting a specific disease process and the mechanistic reasons for heterogeneity in outcome are important challenges in emergency care research. Other research priorities include the need to elucidate the timing, sequence, and duration of causal molecular and cellular events involved in time-critical illnesses and injuries, and the development of treatments capable of halting or reversing them; the need for novel animal models; and the need to understand why there are regional differences in outcome for the same disease processes. Important barriers to emergency care research include a limited number of trained investigators and experienced mentors, limited research infrastructure and support, and regulatory hurdles. The science of emergency care may be advanced by facilitating the following: (1) training emergency care investigators with research training programs; (2) developing emergency care clinical research networks; (3) integrating emergency care research into Clinical and Translational Science Awards; (4) developing emergency carespecific initiatives within the existing structure of NIH institutes and centers; (5) involving emergency specialists in grant review and research advisory processes; (6) supporting learn-phase or small, clinical trials; and (7) performing research to address ethical and regulatory issues. Conclusion: Enhancing the research base supporting the care of medical and surgical emergencies will require progress in specific mechanistic, translational, and clinical domains; effective collaboration of academic investigators across traditional clinical and scientific boundaries; federal support of research in high-priority areas; and overcoming limitations in available infrastructure, research training, and access to patient populations.

AB - Study objective: In 2003, the Institute of Medicine Committee on the Future of Emergency Care in the United States Health System convened and identified a crisis in emergency care in the United States, including a need to enhance the research base for emergency care. As a result, the National Institutes of Health (NIH) formed an NIH Task Force on Research in Emergency Medicine to enhance NIH support for emergency care research. Members of the NIH Task Force and academic leaders in emergency care participated in 3 roundtable discussions to prioritize current opportunities for enhancing and conducting emergency care research. The objectives of these discussions were to identify key research questions essential to advancing the scientific underpinnings of emergency care and to discuss the barriers and best means to advance research by exploring the role of research networks and collaboration between the NIH and the emergency care community. Methods: The Medical-Surgical Research Roundtable was convened on April 30 to May 1, 2009. Before the roundtable, the emergency care domains to be discussed were selected and experts in each of the fields were invited to participate in the roundtable. Domain experts were asked to identify research priorities and challenges and separate them into mechanistic, translational, and clinical categories. After the conference, the lists were circulated among the participants and revised to reach a consensus. Results: Emergency care research is characterized by focus on the timing, sequence, and time sensitivity of disease processes and treatment effects. Rapidly identifying the phenotype and genotype of patients manifesting a specific disease process and the mechanistic reasons for heterogeneity in outcome are important challenges in emergency care research. Other research priorities include the need to elucidate the timing, sequence, and duration of causal molecular and cellular events involved in time-critical illnesses and injuries, and the development of treatments capable of halting or reversing them; the need for novel animal models; and the need to understand why there are regional differences in outcome for the same disease processes. Important barriers to emergency care research include a limited number of trained investigators and experienced mentors, limited research infrastructure and support, and regulatory hurdles. The science of emergency care may be advanced by facilitating the following: (1) training emergency care investigators with research training programs; (2) developing emergency care clinical research networks; (3) integrating emergency care research into Clinical and Translational Science Awards; (4) developing emergency carespecific initiatives within the existing structure of NIH institutes and centers; (5) involving emergency specialists in grant review and research advisory processes; (6) supporting learn-phase or small, clinical trials; and (7) performing research to address ethical and regulatory issues. Conclusion: Enhancing the research base supporting the care of medical and surgical emergencies will require progress in specific mechanistic, translational, and clinical domains; effective collaboration of academic investigators across traditional clinical and scientific boundaries; federal support of research in high-priority areas; and overcoming limitations in available infrastructure, research training, and access to patient populations.

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