Successful repair of esophageal injury using an elastin based biomaterial patch

Michio Kajitani, Yasmin Wadia, Monica Hinds, Jeffrey Teach, Kim R. Swartz, Kenton Gregory

Research output: Contribution to journalArticle

42 Citations (Scopus)

Abstract

An esophageal injury with significant tissue loss is very difficult to repair. We conducted an in vivo study to test our elastin based acellular biomaterial patch to repair such defect. The patch was made from porcine aorta, by decellularization and sterilization. Collagen fibers were preserved to retain mechanical strength and enhance cellular in-growth. Ten domestic pigs underwent right thoracotomy. A 2 cm circular defect was made on the distal esophagus, excising half its circumference, and was repaired using the biomaterial patch and sutures. Soon after the procedure, the animals resumed oral feeding. They were followed for clinical status, weight gain, barium studies, and endoscopic studies, and were killed after 6 weeks to 4 months. All ten animals survived long term, with a procedure success rate of 100% (10 of 10). With the exception of one pneumothorax, no complications occurred, and all animals resumed oral feeding and gained weight. Endoscopic studies showed mucosal coverage by 6 weeks, with minimal stricture at the repair site. Excised specimens showed complete mucosal coverage with regeneration of all three layers. Our biomaterial patch can be used safely and reliably for repair of esophageal injury with significant tissue loss when repaired immediately as in our experiment.

Original languageEnglish (US)
Pages (from-to)342-345
Number of pages4
JournalASAIO Journal
Volume47
Issue number4
StatePublished - 2001

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Elastin
Biocompatible Materials
Biomaterials
Repair
Animals
Wounds and Injuries
Sus scrofa
Pneumothorax
Thoracotomy
Barium
Tissue
Defects
Sutures
Esophagus
Weight Gain
Aorta
Regeneration
Pathologic Constriction
Swine
Collagen

ASJC Scopus subject areas

  • Biophysics
  • Bioengineering

Cite this

Successful repair of esophageal injury using an elastin based biomaterial patch. / Kajitani, Michio; Wadia, Yasmin; Hinds, Monica; Teach, Jeffrey; Swartz, Kim R.; Gregory, Kenton.

In: ASAIO Journal, Vol. 47, No. 4, 2001, p. 342-345.

Research output: Contribution to journalArticle

Kajitani, M, Wadia, Y, Hinds, M, Teach, J, Swartz, KR & Gregory, K 2001, 'Successful repair of esophageal injury using an elastin based biomaterial patch', ASAIO Journal, vol. 47, no. 4, pp. 342-345.
Kajitani, Michio ; Wadia, Yasmin ; Hinds, Monica ; Teach, Jeffrey ; Swartz, Kim R. ; Gregory, Kenton. / Successful repair of esophageal injury using an elastin based biomaterial patch. In: ASAIO Journal. 2001 ; Vol. 47, No. 4. pp. 342-345.
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