Subsensitivity of the norepinephrine receptor-coupled adenylate cyclase system in brain: Effects of Nisoxetine versus fluoxetine

Radhakanta Mishira, Aaron Janowsky, Fridolin Sulser

Research output: Contribution to journalArticlepeer-review

46 Scopus citations

Abstract

Chronic administration of the norepinephrine (NE) reuptake inhibitor nisoxetine reduced the sensitivity of the NE receptor-coupled adenylate cyclase system in rat cortex. This subsensitivity, unlike that caused by desipramine (DMI), was not related to a reduction in specific β-adrenergic receptor binding. The specific serotonin reuptake inhibitor fluoxetine had no effect on either neurohormonal sensitivity or 3H-dihydroalprenolol binding.

Original languageEnglish (US)
Pages (from-to)379-382
Number of pages4
JournalEuropean Journal of Pharmacology
Volume60
Issue number4
DOIs
StatePublished - Dec 20 1979

Keywords

  • Cyclic AMP
  • Fluoxetine
  • H-Dihydroalprenolol binding
  • NE receptors
  • Nisoxetine
  • Subsensitivity

ASJC Scopus subject areas

  • Pharmacology

Fingerprint Dive into the research topics of 'Subsensitivity of the norepinephrine receptor-coupled adenylate cyclase system in brain: Effects of Nisoxetine versus fluoxetine'. Together they form a unique fingerprint.

Cite this