Studies on the glucocorticoid feedback control of acth secretion

John Kendall, C. Allen

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Implants of cortisol acetate in the median eminence of intact rats depressed all measures of adrenocortical function compared with rats which had received cholesterol in the median eminence or an equal amount of cortisol acetate implanted in the cerebral cortex. Lesions in the median eminence of intact rats also depressed adrenocortical function. In contrast, neither implants of cortisol acetate nor lesions in the median eminence depressed adrenocortical function in hypophysectomized rats bearing 10 heterotopic pituitaries (H-T). A large dose of dexamethasone (100 µg/100 g) given systemically suppressed adrenocortical function in both intact and H-T rats. Additionally, implants of cortisol acetate in the median eminence were followed in 2 weeks by adrenal atrophy in intact rats, whereas the adrenal size of H-T rats was unaffected. These findings suggest that the median eminence does not play an important role in feedback control of heterotopic pituitary ACTH secretion. The median eminence may be of importance in feedback regulation of ACTH in intact rats only by virtue of its location at the origin of the pituitary stalk where the hypophyseal blood supply begins, rather than because of any specialized control it exerts on ACTH secretion.

Original languageEnglish (US)
Pages (from-to)1968-1405
Number of pages564
JournalEndocrinology
Volume82
Issue number2
DOIs
StatePublished - 1968

Fingerprint

Median Eminence
Glucocorticoids
Hydrocortisone
Acetates
Adrenocorticotropic Hormone
Pituitary Gland
Cerebral Cortex
Dexamethasone
Atrophy
Cholesterol

ASJC Scopus subject areas

  • Endocrinology

Cite this

Studies on the glucocorticoid feedback control of acth secretion. / Kendall, John; Allen, C.

In: Endocrinology, Vol. 82, No. 2, 1968, p. 1968-1405.

Research output: Contribution to journalArticle

Kendall, John ; Allen, C. / Studies on the glucocorticoid feedback control of acth secretion. In: Endocrinology. 1968 ; Vol. 82, No. 2. pp. 1968-1405.
@article{96346e270c514039ac0ceac25baad9e6,
title = "Studies on the glucocorticoid feedback control of acth secretion",
abstract = "Implants of cortisol acetate in the median eminence of intact rats depressed all measures of adrenocortical function compared with rats which had received cholesterol in the median eminence or an equal amount of cortisol acetate implanted in the cerebral cortex. Lesions in the median eminence of intact rats also depressed adrenocortical function. In contrast, neither implants of cortisol acetate nor lesions in the median eminence depressed adrenocortical function in hypophysectomized rats bearing 10 heterotopic pituitaries (H-T). A large dose of dexamethasone (100 µg/100 g) given systemically suppressed adrenocortical function in both intact and H-T rats. Additionally, implants of cortisol acetate in the median eminence were followed in 2 weeks by adrenal atrophy in intact rats, whereas the adrenal size of H-T rats was unaffected. These findings suggest that the median eminence does not play an important role in feedback control of heterotopic pituitary ACTH secretion. The median eminence may be of importance in feedback regulation of ACTH in intact rats only by virtue of its location at the origin of the pituitary stalk where the hypophyseal blood supply begins, rather than because of any specialized control it exerts on ACTH secretion.",
author = "John Kendall and C. Allen",
year = "1968",
doi = "10.1210/endo-82-2-397",
language = "English (US)",
volume = "82",
pages = "1968--1405",
journal = "Endocrinology",
issn = "0013-7227",
publisher = "The Endocrine Society",
number = "2",

}

TY - JOUR

T1 - Studies on the glucocorticoid feedback control of acth secretion

AU - Kendall, John

AU - Allen, C.

PY - 1968

Y1 - 1968

N2 - Implants of cortisol acetate in the median eminence of intact rats depressed all measures of adrenocortical function compared with rats which had received cholesterol in the median eminence or an equal amount of cortisol acetate implanted in the cerebral cortex. Lesions in the median eminence of intact rats also depressed adrenocortical function. In contrast, neither implants of cortisol acetate nor lesions in the median eminence depressed adrenocortical function in hypophysectomized rats bearing 10 heterotopic pituitaries (H-T). A large dose of dexamethasone (100 µg/100 g) given systemically suppressed adrenocortical function in both intact and H-T rats. Additionally, implants of cortisol acetate in the median eminence were followed in 2 weeks by adrenal atrophy in intact rats, whereas the adrenal size of H-T rats was unaffected. These findings suggest that the median eminence does not play an important role in feedback control of heterotopic pituitary ACTH secretion. The median eminence may be of importance in feedback regulation of ACTH in intact rats only by virtue of its location at the origin of the pituitary stalk where the hypophyseal blood supply begins, rather than because of any specialized control it exerts on ACTH secretion.

AB - Implants of cortisol acetate in the median eminence of intact rats depressed all measures of adrenocortical function compared with rats which had received cholesterol in the median eminence or an equal amount of cortisol acetate implanted in the cerebral cortex. Lesions in the median eminence of intact rats also depressed adrenocortical function. In contrast, neither implants of cortisol acetate nor lesions in the median eminence depressed adrenocortical function in hypophysectomized rats bearing 10 heterotopic pituitaries (H-T). A large dose of dexamethasone (100 µg/100 g) given systemically suppressed adrenocortical function in both intact and H-T rats. Additionally, implants of cortisol acetate in the median eminence were followed in 2 weeks by adrenal atrophy in intact rats, whereas the adrenal size of H-T rats was unaffected. These findings suggest that the median eminence does not play an important role in feedback control of heterotopic pituitary ACTH secretion. The median eminence may be of importance in feedback regulation of ACTH in intact rats only by virtue of its location at the origin of the pituitary stalk where the hypophyseal blood supply begins, rather than because of any specialized control it exerts on ACTH secretion.

UR - http://www.scopus.com/inward/record.url?scp=85003106711&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85003106711&partnerID=8YFLogxK

U2 - 10.1210/endo-82-2-397

DO - 10.1210/endo-82-2-397

M3 - Article

C2 - 4378097

AN - SCOPUS:85003106711

VL - 82

SP - 1968

EP - 1405

JO - Endocrinology

JF - Endocrinology

SN - 0013-7227

IS - 2

ER -