Structure of the Human Vasoactive Intestinal Polypeptide Gene

Toshihiko Tsukada, Sharon J. Horovitch, Marc R. Montminy, Gail Mandel, Richard H. Goodman

Research output: Contribution to journalArticle

79 Scopus citations

Abstract

Vasoactive intestinal polypeptide (VIP) is a 28-amino-acid hormone produced primarily by neural tissues. The amino acid sequence of VIP is similar to that of a number of gastrointestinal hormones, including glucagon and secretin. VIP is synthesized as part of a polyprotein, pre-proVIP, which generates, in addition to VIP, an additional bioactive peptide known as PHM. As a first step toward understanding the molecular basis of pre-proVIP gene expression, we have isolated the pre-proVIP gene and have determined its structure. The gene is approximately 9 kb long and is interrupted by six introns which appear to divide the gene into functional domains. One of the introns occurs within the 3′-untranslated region of the gene.

Original languageEnglish (US)
Pages (from-to)293-300
Number of pages8
JournalDNA
Volume4
Issue number4
DOIs
StatePublished - Aug 1985

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Genetics

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