Structure of the human vasoactive intestinal polypeptide gene

T. Tsukada, S. J. Horovitch, M. R. Montminy, Gail Mandel, Richard Goodman

Research output: Contribution to journalArticle

78 Citations (Scopus)

Abstract

Vasoactive intestinal polypeptide (VIP) is a 28-amino-acid hormone produced primarily by neural tissues. The amino acid sequence of VIP is similar to that of a number of gastrointestinal hormones, including glucagon and secretin. VIP is synthesized as part of a polyprotein, pre-proVIP, which generates, in addition to VIP, an additional bioactive peptide known as PHM. As a first step toward understanding the molecular basis of pre-proVIP gene expression, we have isolated the pre-proVIP gene and have determined its structure. The gene is approximately 9 kb long and is interrupted by six introns which appear to divide the gene into functional domains. One of the introns occurs within the 3'-untranslated region of the gene.

Original languageEnglish (US)
Pages (from-to)293-300
Number of pages8
JournalDNA
Volume4
Issue number4
StatePublished - 1985
Externally publishedYes

Fingerprint

Vasoactive Intestinal Peptide
Genes
Introns
Gastrointestinal Hormones
Amino Acids
Polyproteins
Secretin
3' Untranslated Regions
Glucagon
Gene expression
Amino Acid Sequence
Hormones
Tissue
Gene Expression
Peptides

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Genetics

Cite this

Tsukada, T., Horovitch, S. J., Montminy, M. R., Mandel, G., & Goodman, R. (1985). Structure of the human vasoactive intestinal polypeptide gene. DNA, 4(4), 293-300.

Structure of the human vasoactive intestinal polypeptide gene. / Tsukada, T.; Horovitch, S. J.; Montminy, M. R.; Mandel, Gail; Goodman, Richard.

In: DNA, Vol. 4, No. 4, 1985, p. 293-300.

Research output: Contribution to journalArticle

Tsukada, T, Horovitch, SJ, Montminy, MR, Mandel, G & Goodman, R 1985, 'Structure of the human vasoactive intestinal polypeptide gene', DNA, vol. 4, no. 4, pp. 293-300.
Tsukada T, Horovitch SJ, Montminy MR, Mandel G, Goodman R. Structure of the human vasoactive intestinal polypeptide gene. DNA. 1985;4(4):293-300.
Tsukada, T. ; Horovitch, S. J. ; Montminy, M. R. ; Mandel, Gail ; Goodman, Richard. / Structure of the human vasoactive intestinal polypeptide gene. In: DNA. 1985 ; Vol. 4, No. 4. pp. 293-300.
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