Structural neuroimaging correlates of alcohol and cannabis use in adolescents and adults

Rachel E. Thayer, Sophie Yorkwilliams, Hollis C. Karoly, Amithrupa Sabbineni, Sarah Feldstein Ewing, Angela D. Bryan, Kent E. Hutchison

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Background and Aims: Chronic alcohol use is associated with lower gray matter volume, and we reported recently that alcohol use showed negative associations with widespread gray matter (GM) volume even among young adults. The current study aimed to test the strength of association between (1) alcohol use and GM volume; (2) alcohol use and white matter (WM) integrity; (3) cannabis use and GM volume; and (4) cannabis use and WM integrity among adults and adolescents. Design and Setting: General linear models within large pooled cross-sectional samples of adolescents and adults who had participated in studies collecting substance use and neuroimaging data in the southwestern United States. Participants: The current analysis included adults aged 18-55 years (n = 853) and adolescents aged 14-18 years (n = 439) with a range of alcohol and cannabis use. Measurements: The dependent variable was GM volume or WM integrity, with key predictors of alcohol use [Alcohol Use Disorders Identification Test (AUDIT) score] and cannabis use (past 30-day use). Findings: Alcohol use showed large clusters of negative associations (ηp 2 = 0.028-0.145, P < 0.001) with GM volume among adults and to a lesser extent (one cluster; ηp 2 = 0.070, P < 0.05) among adolescents. Large clusters showed significant associations (ηp 2 = 0.050-0.124, P < 0.001) of higher alcohol use with poorer WM integrity, whereas adolescents showed no significant associations between alcohol use and WM. No associations were observed between structural measures and past 30-day cannabis use in adults or adolescents. Conclusions: Alcohol use severity is associated with widespread lower gray matter volume and white matter integrity in adults, and with lower gray matter volume in adolescents.

Original languageEnglish (US)
JournalAddiction
DOIs
StateAccepted/In press - 2017

Fingerprint

Cannabis
Neuroimaging
Alcohols
Southwestern United States
Gray Matter
White Matter
Young Adult
Linear Models

Keywords

  • Adolescents
  • Adults
  • Alcohol use
  • Cannabis use
  • Diffusion tensor imaging
  • Neuroimaging
  • Voxel-based morphometry

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Psychiatry and Mental health

Cite this

Thayer, R. E., Yorkwilliams, S., Karoly, H. C., Sabbineni, A., Feldstein Ewing, S., Bryan, A. D., & Hutchison, K. E. (Accepted/In press). Structural neuroimaging correlates of alcohol and cannabis use in adolescents and adults. Addiction. https://doi.org/10.1111/add.13923

Structural neuroimaging correlates of alcohol and cannabis use in adolescents and adults. / Thayer, Rachel E.; Yorkwilliams, Sophie; Karoly, Hollis C.; Sabbineni, Amithrupa; Feldstein Ewing, Sarah; Bryan, Angela D.; Hutchison, Kent E.

In: Addiction, 2017.

Research output: Contribution to journalArticle

Thayer, Rachel E. ; Yorkwilliams, Sophie ; Karoly, Hollis C. ; Sabbineni, Amithrupa ; Feldstein Ewing, Sarah ; Bryan, Angela D. ; Hutchison, Kent E. / Structural neuroimaging correlates of alcohol and cannabis use in adolescents and adults. In: Addiction. 2017.
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abstract = "Background and Aims: Chronic alcohol use is associated with lower gray matter volume, and we reported recently that alcohol use showed negative associations with widespread gray matter (GM) volume even among young adults. The current study aimed to test the strength of association between (1) alcohol use and GM volume; (2) alcohol use and white matter (WM) integrity; (3) cannabis use and GM volume; and (4) cannabis use and WM integrity among adults and adolescents. Design and Setting: General linear models within large pooled cross-sectional samples of adolescents and adults who had participated in studies collecting substance use and neuroimaging data in the southwestern United States. Participants: The current analysis included adults aged 18-55 years (n = 853) and adolescents aged 14-18 years (n = 439) with a range of alcohol and cannabis use. Measurements: The dependent variable was GM volume or WM integrity, with key predictors of alcohol use [Alcohol Use Disorders Identification Test (AUDIT) score] and cannabis use (past 30-day use). Findings: Alcohol use showed large clusters of negative associations (ηp 2 = 0.028-0.145, P < 0.001) with GM volume among adults and to a lesser extent (one cluster; ηp 2 = 0.070, P < 0.05) among adolescents. Large clusters showed significant associations (ηp 2 = 0.050-0.124, P < 0.001) of higher alcohol use with poorer WM integrity, whereas adolescents showed no significant associations between alcohol use and WM. No associations were observed between structural measures and past 30-day cannabis use in adults or adolescents. Conclusions: Alcohol use severity is associated with widespread lower gray matter volume and white matter integrity in adults, and with lower gray matter volume in adolescents.",
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AU - Thayer, Rachel E.

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AU - Karoly, Hollis C.

AU - Sabbineni, Amithrupa

AU - Feldstein Ewing, Sarah

AU - Bryan, Angela D.

AU - Hutchison, Kent E.

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N2 - Background and Aims: Chronic alcohol use is associated with lower gray matter volume, and we reported recently that alcohol use showed negative associations with widespread gray matter (GM) volume even among young adults. The current study aimed to test the strength of association between (1) alcohol use and GM volume; (2) alcohol use and white matter (WM) integrity; (3) cannabis use and GM volume; and (4) cannabis use and WM integrity among adults and adolescents. Design and Setting: General linear models within large pooled cross-sectional samples of adolescents and adults who had participated in studies collecting substance use and neuroimaging data in the southwestern United States. Participants: The current analysis included adults aged 18-55 years (n = 853) and adolescents aged 14-18 years (n = 439) with a range of alcohol and cannabis use. Measurements: The dependent variable was GM volume or WM integrity, with key predictors of alcohol use [Alcohol Use Disorders Identification Test (AUDIT) score] and cannabis use (past 30-day use). Findings: Alcohol use showed large clusters of negative associations (ηp 2 = 0.028-0.145, P < 0.001) with GM volume among adults and to a lesser extent (one cluster; ηp 2 = 0.070, P < 0.05) among adolescents. Large clusters showed significant associations (ηp 2 = 0.050-0.124, P < 0.001) of higher alcohol use with poorer WM integrity, whereas adolescents showed no significant associations between alcohol use and WM. No associations were observed between structural measures and past 30-day cannabis use in adults or adolescents. Conclusions: Alcohol use severity is associated with widespread lower gray matter volume and white matter integrity in adults, and with lower gray matter volume in adolescents.

AB - Background and Aims: Chronic alcohol use is associated with lower gray matter volume, and we reported recently that alcohol use showed negative associations with widespread gray matter (GM) volume even among young adults. The current study aimed to test the strength of association between (1) alcohol use and GM volume; (2) alcohol use and white matter (WM) integrity; (3) cannabis use and GM volume; and (4) cannabis use and WM integrity among adults and adolescents. Design and Setting: General linear models within large pooled cross-sectional samples of adolescents and adults who had participated in studies collecting substance use and neuroimaging data in the southwestern United States. Participants: The current analysis included adults aged 18-55 years (n = 853) and adolescents aged 14-18 years (n = 439) with a range of alcohol and cannabis use. Measurements: The dependent variable was GM volume or WM integrity, with key predictors of alcohol use [Alcohol Use Disorders Identification Test (AUDIT) score] and cannabis use (past 30-day use). Findings: Alcohol use showed large clusters of negative associations (ηp 2 = 0.028-0.145, P < 0.001) with GM volume among adults and to a lesser extent (one cluster; ηp 2 = 0.070, P < 0.05) among adolescents. Large clusters showed significant associations (ηp 2 = 0.050-0.124, P < 0.001) of higher alcohol use with poorer WM integrity, whereas adolescents showed no significant associations between alcohol use and WM. No associations were observed between structural measures and past 30-day cannabis use in adults or adolescents. Conclusions: Alcohol use severity is associated with widespread lower gray matter volume and white matter integrity in adults, and with lower gray matter volume in adolescents.

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KW - Diffusion tensor imaging

KW - Neuroimaging

KW - Voxel-based morphometry

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