Structural and functional analysis of the 5'-transcription control region for the human 1/4 -HS glycoprotein gene

F. Banine, C. Gangneux, J. P. Lebreton, T. Frebourg, J. P. Salier

    Research output: Contribution to journalArticle

    9 Scopus citations

    Abstract

    The human alpha2-HS glycoprotein (A2HS) and rat phosphoprotein of Mr 63000 (pp63) are homologous plasma proteins and members of the fetuin superfamily. A2HS is involved in important functions such as inhbition of the tyrosine kinase activity of the insulin receptor, regulation of calcium metabolism and osteogenesis as well as protease inhibitory activity. We report an analysis of the 5' transcription control region (4 kb) of the A2HS gene. Its most proximal 300 nt display a very potent transcription activity. The latter is likely accounted for by C/EBP and NF1 binding sites that are conserved from the human A2HS gene to the rat pp63 gene. In contrast, these human and rat genes appear to largely diverge beyond their proximal promoter.

    Original languageEnglish (US)
    Pages (from-to)1-8
    Number of pages8
    JournalBiochimica et Biophysica Acta - Gene Structure and Expression
    Volume1398
    Issue number1
    DOIs
    StatePublished - May 29 1998

    Keywords

    • Hepatocyte
    • Liver
    • Liver-enriched nuclear factor
    • Plasma protein
    • Transcription

    ASJC Scopus subject areas

    • Structural Biology
    • Biophysics
    • Biochemistry
    • Genetics

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