Strain differences in pituitary β-endorphin and ACTH content in inbred mice

John C. Crabbe; Richard G. Allen; N. Donna Gaudette; Emmett R. Young; Ann Kosobud; Julianne Stack

doi:10.1016/0006-8993(81)90286-9

Strain differences in pituitary β-endorphin and ACTH content in inbred mice

John C. Crabbe, Richard G. Allen, N. Donna Gaudette, Emmett R. Young, Ann Kosobud, Julianne Stack

Behavioral Neuroscience

Research output: Contribution to journal › Article › peer-review

28 Scopus citations

Abstract

The whole pituitary contents of β-endorphin and ACTH were found to vary widely among 5 inbred strains of mice. β-endorphin values were 2.5-fold different and ACTH values 1.5-fold. Strains low in β-endorphin were also low in ACTH. The existence of genetic differences raises the possibility that there exist, or can be developed, strains with extremely low or high levels of these peptides that would aid research directed at elucidating the physiology of opioid peptides.

Original language	English (US)
Pages (from-to)	219-223
Number of pages	5
Journal	Brain research
Volume	219
Issue number	1
DOIs	https://doi.org/10.1016/0006-8993(81)90286-9
State	Published - Aug 24 1981

Keywords

gel electrophoresis
mouse inbred strain
pharmacogenetic
pituitary
radioimmunoassay
strain difference
β-endorphine content

ASJC Scopus subject areas

Neuroscience(all)
Molecular Biology
Clinical Neurology
Developmental Biology

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10.1016/0006-8993(81)90286-9

Cite this

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title = "Strain differences in pituitary β-endorphin and ACTH content in inbred mice",

abstract = "The whole pituitary contents of β-endorphin and ACTH were found to vary widely among 5 inbred strains of mice. β-endorphin values were 2.5-fold different and ACTH values 1.5-fold. Strains low in β-endorphin were also low in ACTH. The existence of genetic differences raises the possibility that there exist, or can be developed, strains with extremely low or high levels of these peptides that would aid research directed at elucidating the physiology of opioid peptides.",

keywords = "gel electrophoresis, mouse inbred strain, pharmacogenetic, pituitary, radioimmunoassay, strain difference, β-endorphine content",

author = "Crabbe, {John C.} and Allen, {Richard G.} and Gaudette, {N. Donna} and Young, {Emmett R.} and Ann Kosobud and Julianne Stack",

note = "Funding Information: We thank H. M. Tesselaar for technical assistance and A. Irwin for preparation of this manuscript. This research was supported by a grant to J.C.C. from the Medical Research Service of the Veterans Administration and by Grant DA 02799 from NIDA to J.C.C. and R.G.A.",

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AU - Allen, Richard G.

AU - Gaudette, N. Donna

AU - Young, Emmett R.

AU - Kosobud, Ann

AU - Stack, Julianne

N1 - Funding Information: We thank H. M. Tesselaar for technical assistance and A. Irwin for preparation of this manuscript. This research was supported by a grant to J.C.C. from the Medical Research Service of the Veterans Administration and by Grant DA 02799 from NIDA to J.C.C. and R.G.A.

PY - 1981/8/24

Y1 - 1981/8/24

N2 - The whole pituitary contents of β-endorphin and ACTH were found to vary widely among 5 inbred strains of mice. β-endorphin values were 2.5-fold different and ACTH values 1.5-fold. Strains low in β-endorphin were also low in ACTH. The existence of genetic differences raises the possibility that there exist, or can be developed, strains with extremely low or high levels of these peptides that would aid research directed at elucidating the physiology of opioid peptides.

AB - The whole pituitary contents of β-endorphin and ACTH were found to vary widely among 5 inbred strains of mice. β-endorphin values were 2.5-fold different and ACTH values 1.5-fold. Strains low in β-endorphin were also low in ACTH. The existence of genetic differences raises the possibility that there exist, or can be developed, strains with extremely low or high levels of these peptides that would aid research directed at elucidating the physiology of opioid peptides.

KW - gel electrophoresis

KW - mouse inbred strain

KW - pharmacogenetic

KW - pituitary

KW - radioimmunoassay

KW - strain difference

KW - β-endorphine content

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Strain differences in pituitary β-endorphin and ACTH content in inbred mice

Abstract

Keywords

ASJC Scopus subject areas

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