Stimulation of cAMP response element (CRE)-mediated transcription during contextual learning

Soren Impey, Dave M. Smith, Karl Obrietan, Rachel Donahue, Christian Wade, Daniel R. Storm

Research output: Contribution to journalArticle

177 Citations (Scopus)

Abstract

Recent studies suggest that the CREB-CRE transcriptional pathway is pivotal in the formation of some types of long-term memory. However, it has not been demonstrated that stimuli that induce learning and memory activate CRE-mediated gene expression. To address this issue, we used a mouse strain transgenic for a CRE-lac Z reporter to examine the effects of hippocampus-dependent learning on CRE-mediated gene expression in the brain. Training for contextual conditioning or passive avoidance led to significant increases in CRE-dependent gene expression in areas CA1 and CA3 of the hippocampus. Auditory cue fear-conditioning, which is amygdala dependent, was associated with increased CRE-mediated gene expression in the amygdala, but not the hippocampus. These data demonstrate that learning in response to behavioral conditioning activates the CRE transcriptional pathway in specific areas of brain.

Original languageEnglish (US)
Pages (from-to)595-601
Number of pages7
JournalMolecular Cell
Volume1
Issue number7
StatePublished - 1998
Externally publishedYes

Fingerprint

Response Elements
Learning
Gene Expression
Hippocampus
Amygdala
Long-Term Memory
Brain
Transgenic Mice
Fear
Cues
Conditioning (Psychology)

ASJC Scopus subject areas

  • Molecular Biology

Cite this

Impey, S., Smith, D. M., Obrietan, K., Donahue, R., Wade, C., & Storm, D. R. (1998). Stimulation of cAMP response element (CRE)-mediated transcription during contextual learning. Molecular Cell, 1(7), 595-601.

Stimulation of cAMP response element (CRE)-mediated transcription during contextual learning. / Impey, Soren; Smith, Dave M.; Obrietan, Karl; Donahue, Rachel; Wade, Christian; Storm, Daniel R.

In: Molecular Cell, Vol. 1, No. 7, 1998, p. 595-601.

Research output: Contribution to journalArticle

Impey, S, Smith, DM, Obrietan, K, Donahue, R, Wade, C & Storm, DR 1998, 'Stimulation of cAMP response element (CRE)-mediated transcription during contextual learning', Molecular Cell, vol. 1, no. 7, pp. 595-601.
Impey, Soren ; Smith, Dave M. ; Obrietan, Karl ; Donahue, Rachel ; Wade, Christian ; Storm, Daniel R. / Stimulation of cAMP response element (CRE)-mediated transcription during contextual learning. In: Molecular Cell. 1998 ; Vol. 1, No. 7. pp. 595-601.
@article{28dc3e9069a946939e128e0e2752dcf8,
title = "Stimulation of cAMP response element (CRE)-mediated transcription during contextual learning",
abstract = "Recent studies suggest that the CREB-CRE transcriptional pathway is pivotal in the formation of some types of long-term memory. However, it has not been demonstrated that stimuli that induce learning and memory activate CRE-mediated gene expression. To address this issue, we used a mouse strain transgenic for a CRE-lac Z reporter to examine the effects of hippocampus-dependent learning on CRE-mediated gene expression in the brain. Training for contextual conditioning or passive avoidance led to significant increases in CRE-dependent gene expression in areas CA1 and CA3 of the hippocampus. Auditory cue fear-conditioning, which is amygdala dependent, was associated with increased CRE-mediated gene expression in the amygdala, but not the hippocampus. These data demonstrate that learning in response to behavioral conditioning activates the CRE transcriptional pathway in specific areas of brain.",
author = "Soren Impey and Smith, {Dave M.} and Karl Obrietan and Rachel Donahue and Christian Wade and Storm, {Daniel R.}",
year = "1998",
language = "English (US)",
volume = "1",
pages = "595--601",
journal = "Molecular Cell",
issn = "1097-2765",
publisher = "Cell Press",
number = "7",

}

TY - JOUR

T1 - Stimulation of cAMP response element (CRE)-mediated transcription during contextual learning

AU - Impey, Soren

AU - Smith, Dave M.

AU - Obrietan, Karl

AU - Donahue, Rachel

AU - Wade, Christian

AU - Storm, Daniel R.

PY - 1998

Y1 - 1998

N2 - Recent studies suggest that the CREB-CRE transcriptional pathway is pivotal in the formation of some types of long-term memory. However, it has not been demonstrated that stimuli that induce learning and memory activate CRE-mediated gene expression. To address this issue, we used a mouse strain transgenic for a CRE-lac Z reporter to examine the effects of hippocampus-dependent learning on CRE-mediated gene expression in the brain. Training for contextual conditioning or passive avoidance led to significant increases in CRE-dependent gene expression in areas CA1 and CA3 of the hippocampus. Auditory cue fear-conditioning, which is amygdala dependent, was associated with increased CRE-mediated gene expression in the amygdala, but not the hippocampus. These data demonstrate that learning in response to behavioral conditioning activates the CRE transcriptional pathway in specific areas of brain.

AB - Recent studies suggest that the CREB-CRE transcriptional pathway is pivotal in the formation of some types of long-term memory. However, it has not been demonstrated that stimuli that induce learning and memory activate CRE-mediated gene expression. To address this issue, we used a mouse strain transgenic for a CRE-lac Z reporter to examine the effects of hippocampus-dependent learning on CRE-mediated gene expression in the brain. Training for contextual conditioning or passive avoidance led to significant increases in CRE-dependent gene expression in areas CA1 and CA3 of the hippocampus. Auditory cue fear-conditioning, which is amygdala dependent, was associated with increased CRE-mediated gene expression in the amygdala, but not the hippocampus. These data demonstrate that learning in response to behavioral conditioning activates the CRE transcriptional pathway in specific areas of brain.

UR - http://www.scopus.com/inward/record.url?scp=33644681165&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33644681165&partnerID=8YFLogxK

M3 - Article

VL - 1

SP - 595

EP - 601

JO - Molecular Cell

JF - Molecular Cell

SN - 1097-2765

IS - 7

ER -