Stimulation of active E-rosette forming lymphocytes from multiple sclerosis patients by gangliosides and cerebrosides

Halina Offner, Grzegorz Konat

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

An active subpopulation of blood T-lymphocytes, characterized by rapid (4 min) rosette formation with sheep erythrocytes was measured in multiple sclerosis (MS) patients, other neurological diseases (OND) and healthy subjects after 15 min incubation with low doses (0.1-5 pg) of brain cerebrosides and gangliosides. A 15% rise in the active E-rosettes after incubation with antigens was indicative of a response to given antigen. Peripheral blood lymphocytes from all 35 patients with MS responded to brain cerebrosides in the active E-rosette test (AER). Lymphocytes from 33 MS patients also responded to brain gangliosides. Three out of 26 other neurological patients were stimulated by cerebrosides and gangliosides. Fifteen healthy subjects did not respond to any antigen in the AER test. The significance of the results in relation to the process of demyelination is discussed.

Original languageEnglish (US)
Pages (from-to)101-104
Number of pages4
JournalJournal of the Neurological Sciences
Volume46
Issue number1
DOIs
StatePublished - 1980
Externally publishedYes

Fingerprint

Cerebrosides
Gangliosides
Multiple Sclerosis
Lymphocytes
Antigens
Healthy Volunteers
Brain
Rosette Formation
Demyelinating Diseases
Sheep
Erythrocytes
T-Lymphocytes

ASJC Scopus subject areas

  • Aging
  • Clinical Neurology
  • Surgery
  • Neuroscience(all)
  • Developmental Neuroscience
  • Neurology

Cite this

Stimulation of active E-rosette forming lymphocytes from multiple sclerosis patients by gangliosides and cerebrosides. / Offner, Halina; Konat, Grzegorz.

In: Journal of the Neurological Sciences, Vol. 46, No. 1, 1980, p. 101-104.

Research output: Contribution to journalArticle

@article{9c6479f09d1d4f729468e590d71dd7c8,
title = "Stimulation of active E-rosette forming lymphocytes from multiple sclerosis patients by gangliosides and cerebrosides",
abstract = "An active subpopulation of blood T-lymphocytes, characterized by rapid (4 min) rosette formation with sheep erythrocytes was measured in multiple sclerosis (MS) patients, other neurological diseases (OND) and healthy subjects after 15 min incubation with low doses (0.1-5 pg) of brain cerebrosides and gangliosides. A 15{\%} rise in the active E-rosettes after incubation with antigens was indicative of a response to given antigen. Peripheral blood lymphocytes from all 35 patients with MS responded to brain cerebrosides in the active E-rosette test (AER). Lymphocytes from 33 MS patients also responded to brain gangliosides. Three out of 26 other neurological patients were stimulated by cerebrosides and gangliosides. Fifteen healthy subjects did not respond to any antigen in the AER test. The significance of the results in relation to the process of demyelination is discussed.",
author = "Halina Offner and Grzegorz Konat",
year = "1980",
doi = "10.1016/0022-510X(80)90046-5",
language = "English (US)",
volume = "46",
pages = "101--104",
journal = "Journal of the Neurological Sciences",
issn = "0022-510X",
publisher = "Elsevier",
number = "1",

}

TY - JOUR

T1 - Stimulation of active E-rosette forming lymphocytes from multiple sclerosis patients by gangliosides and cerebrosides

AU - Offner, Halina

AU - Konat, Grzegorz

PY - 1980

Y1 - 1980

N2 - An active subpopulation of blood T-lymphocytes, characterized by rapid (4 min) rosette formation with sheep erythrocytes was measured in multiple sclerosis (MS) patients, other neurological diseases (OND) and healthy subjects after 15 min incubation with low doses (0.1-5 pg) of brain cerebrosides and gangliosides. A 15% rise in the active E-rosettes after incubation with antigens was indicative of a response to given antigen. Peripheral blood lymphocytes from all 35 patients with MS responded to brain cerebrosides in the active E-rosette test (AER). Lymphocytes from 33 MS patients also responded to brain gangliosides. Three out of 26 other neurological patients were stimulated by cerebrosides and gangliosides. Fifteen healthy subjects did not respond to any antigen in the AER test. The significance of the results in relation to the process of demyelination is discussed.

AB - An active subpopulation of blood T-lymphocytes, characterized by rapid (4 min) rosette formation with sheep erythrocytes was measured in multiple sclerosis (MS) patients, other neurological diseases (OND) and healthy subjects after 15 min incubation with low doses (0.1-5 pg) of brain cerebrosides and gangliosides. A 15% rise in the active E-rosettes after incubation with antigens was indicative of a response to given antigen. Peripheral blood lymphocytes from all 35 patients with MS responded to brain cerebrosides in the active E-rosette test (AER). Lymphocytes from 33 MS patients also responded to brain gangliosides. Three out of 26 other neurological patients were stimulated by cerebrosides and gangliosides. Fifteen healthy subjects did not respond to any antigen in the AER test. The significance of the results in relation to the process of demyelination is discussed.

UR - http://www.scopus.com/inward/record.url?scp=0018875755&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0018875755&partnerID=8YFLogxK

U2 - 10.1016/0022-510X(80)90046-5

DO - 10.1016/0022-510X(80)90046-5

M3 - Article

C2 - 6246211

AN - SCOPUS:0018875755

VL - 46

SP - 101

EP - 104

JO - Journal of the Neurological Sciences

JF - Journal of the Neurological Sciences

SN - 0022-510X

IS - 1

ER -