Steroid regulation of the peptide-mediated increase in cyclic GMP in the nervous system of the hawkmoth, Manduca sexta

David Morton, James W. Truman

Research output: Contribution to journalArticle

47 Citations (Scopus)

Abstract

The action of the peptide, eclosion hormone (EH) on the CNS of Manduca sexta appears to be mediated via the second messenger cGMP. Injections of EH or release of endogenous EH cause a rapid increase in cGMP in the CNS. Cyclic GMP, 8-bromo-cGMP and the phosphodiesterase inhibitors IBMX and theophylline mimic the action of EH in triggering premature ecdysis behavior. The CNS is only sensitive to EH just before ecdysis, both in triggering ecdysis and increasing endogenous cGMP levels. The development of the ability to increase cGMP levels occurs earlier than the behavioral sensitivity and the relative timing of these events is discussed in terms of the likely site for the block in behavioral sensitivity. The steroid hormone 20-hydroxyecdysone is shown to regulate the ability of EH to elevate cGMP levels in the CNS.

Original languageEnglish (US)
Pages (from-to)423-432
Number of pages10
JournalJournal of Comparative Physiology A
Volume157
Issue number4
DOIs
StatePublished - Jul 1985
Externally publishedYes

Fingerprint

eclosion hormone
Manduca
cyclic GMP
Cyclic GMP
Manduca sexta
nervous system
steroid
peptide
Nervous System
steroids
hormone
Steroids
peptides
Molting
Peptides
ecdysis
Aptitude
Ecdysterone
1-Methyl-3-isobutylxanthine
theophylline

ASJC Scopus subject areas

  • Behavioral Neuroscience
  • Neuroscience(all)
  • Physiology (medical)
  • Physiology
  • Animal Science and Zoology

Cite this

Steroid regulation of the peptide-mediated increase in cyclic GMP in the nervous system of the hawkmoth, Manduca sexta. / Morton, David; Truman, James W.

In: Journal of Comparative Physiology A, Vol. 157, No. 4, 07.1985, p. 423-432.

Research output: Contribution to journalArticle

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