This report describes a patient with long-standing virilization caused by the androgen-producing lipoid-cell tumor of the ovary. Detailed studies of androgen secretion, both under basal conditions and after various suppressive and stimulatory tests, were performed. The steroid biosynthetic pattern of the tumor was studied by simultaneous measurements of steroids in the ovarian veins and in peripheral blood, and was subsequently correlated with direct measurements of enzyme activities in excised tumor tissue. Additionally, a detailed investigation of both basal and gonadotropin-releasing hormone-stimulated gonadotropin secretion was performed before and after removal of the tumor.
ASJC Scopus subject areas
- Obstetrics and Gynecology