Stem cells in the trabecular meshwork: Present and future promises

Mary Kelley, A. Y. Rose, Kate Keller, H. Hessle, J. R. Samples, Ted Acott

Research output: Contribution to journalArticle

46 Citations (Scopus)

Abstract

Primary open-angle glaucoma is recognized as a disease of aging, and studies show a relationship between aging and trabecular meshwork (TM) cell density. Human TM cell division occurs primarily in the anterior, non-filtering region. A commonly used glaucoma treatment, laser trabeculoplasty (LTP), triggers and increases cell division, as well as cell migration of these anterior TM cells. These freshly-divided migrating cells repopulate the burned laser sites, suggesting that they are stem cells. Several studies concerning this putative TM stem cell will be discussed.

Original languageEnglish (US)
Pages (from-to)747-751
Number of pages5
JournalExperimental Eye Research
Volume88
Issue number4
DOIs
StatePublished - Apr 30 2009

Fingerprint

Trabecular Meshwork
Stem Cells
Cell Division
Lasers
Trabeculectomy
Glaucoma
Cell Movement
Cell Count

Keywords

  • glaucoma
  • progenitor cells
  • regeneration
  • stem cells
  • trabecular meshwork

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience

Cite this

Stem cells in the trabecular meshwork : Present and future promises. / Kelley, Mary; Rose, A. Y.; Keller, Kate; Hessle, H.; Samples, J. R.; Acott, Ted.

In: Experimental Eye Research, Vol. 88, No. 4, 30.04.2009, p. 747-751.

Research output: Contribution to journalArticle

Kelley, Mary ; Rose, A. Y. ; Keller, Kate ; Hessle, H. ; Samples, J. R. ; Acott, Ted. / Stem cells in the trabecular meshwork : Present and future promises. In: Experimental Eye Research. 2009 ; Vol. 88, No. 4. pp. 747-751.
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