Stem cells in the trabecular meshwork: Present and future promises

M. J. Kelley, A. Y. Rose, K. E. Keller, H. Hessle, J. R. Samples, T. S. Acott

Research output: Contribution to journalReview article

55 Scopus citations

Abstract

Primary open-angle glaucoma is recognized as a disease of aging, and studies show a relationship between aging and trabecular meshwork (TM) cell density. Human TM cell division occurs primarily in the anterior, non-filtering region. A commonly used glaucoma treatment, laser trabeculoplasty (LTP), triggers and increases cell division, as well as cell migration of these anterior TM cells. These freshly-divided migrating cells repopulate the burned laser sites, suggesting that they are stem cells. Several studies concerning this putative TM stem cell will be discussed.

Original languageEnglish (US)
Pages (from-to)747-751
Number of pages5
JournalExperimental Eye Research
Volume88
Issue number4
DOIs
StatePublished - Apr 30 2009

Keywords

  • glaucoma
  • progenitor cells
  • regeneration
  • stem cells
  • trabecular meshwork

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience

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