Spontaneous inhibitory synaptic currents mediated by a g protein-coupled receptor

Stephanie C. Gantz, James R. Bunzow, John T. Williams

Research output: Contribution to journalArticle

44 Scopus citations

Abstract

G protein-coupled receptors (GPCRs) affect many physiological processes by modulating both intrinsic membrane conductances and synaptic transmission. This study describes spontaneous miniature inhibitory postsynaptic currents mediated by vesicular dopamine release acting locally on metabotropic D2 receptors leading to the activation of a G protein-coupled inwardly rectifying potassium conductance. Thus, individual exocytotic events result in spontaneous GPCR-mediated transmission, similar to synaptic activation of classical ligand-gated ion channels

Original languageEnglish (US)
Pages (from-to)807-812
Number of pages6
JournalNeuron
Volume78
Issue number5
DOIs
StatePublished - Jun 5 2013

ASJC Scopus subject areas

  • Neuroscience(all)

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