Spontaneous inhibitory synaptic currents mediated by a g protein-coupled receptor

Stephanie C. Gantz, James R. Bunzow, John Williams

Research output: Contribution to journalArticle

41 Citations (Scopus)

Abstract

G protein-coupled receptors (GPCRs) affect many physiological processes by modulating both intrinsic membrane conductances and synaptic transmission. This study describes spontaneous miniature inhibitory postsynaptic currents mediated by vesicular dopamine release acting locally on metabotropic D2 receptors leading to the activation of a G protein-coupled inwardly rectifying potassium conductance. Thus, individual exocytotic events result in spontaneous GPCR-mediated transmission, similar to synaptic activation of classical ligand-gated ion channels

Original languageEnglish (US)
Pages (from-to)807-812
Number of pages6
JournalNeuron
Volume78
Issue number5
DOIs
StatePublished - Jun 5 2013

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G-Protein-Coupled Receptors
Physiological Phenomena
Ligand-Gated Ion Channels
Inhibitory Postsynaptic Potentials
GTP-Binding Proteins
Synaptic Transmission
Dopamine
Potassium
Proteins
Membranes

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Spontaneous inhibitory synaptic currents mediated by a g protein-coupled receptor. / Gantz, Stephanie C.; Bunzow, James R.; Williams, John.

In: Neuron, Vol. 78, No. 5, 05.06.2013, p. 807-812.

Research output: Contribution to journalArticle

Gantz, Stephanie C. ; Bunzow, James R. ; Williams, John. / Spontaneous inhibitory synaptic currents mediated by a g protein-coupled receptor. In: Neuron. 2013 ; Vol. 78, No. 5. pp. 807-812.
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