Spinal cord and peripheral nerve pathology in AIDS: The roles of cytomegalovirus and human immunodeficiency virus

Marjorie Grafe, C. A. Wiley

Research output: Contribution to journalArticle

78 Citations (Scopus)

Abstract

We examined spinal cords, nerve roots, or peripheral nerves of 27 patients who died with acquired immunodeficiency syndrome (AIDS) for the presence of cytomegalovirus (CMV) and human immunodeficiency virus (HIV) by immunoperoxidase techniques in paraffin-embedded tissue. Vacuolar myelopathy was seen in 8 of 26 spinal cords (31%) and microglial nodules were seen in 13 (50%). All of the patients with lateral column vacuolar myelopathy showed severe brain pathology. HIV antigens had been detected in the brains of 15 (55%) of the 27 patients but were detected in only 3 (11%) of 26 spinal cords and were not localized to regions of vacuolar myelopathy. This suggests that the vacuolar myelopathy may be due to a remote or indirect effect of HIV or other infectious agent. CMV antigens were detected in none of the patients who showed vascuolar myelopathy but were detected in 2 of the 13 with microglial nodules. Focal nerve root or peripheral nerve inflammation was seen in 7 patients; 4 had CMV antigens and none had HIV antigens. CMV appears to be an important cause of inflammatory peripheral neuropathy in AIDS patients.

Original languageEnglish (US)
Pages (from-to)561-566
Number of pages6
JournalAnnals of Neurology
Volume25
Issue number6
StatePublished - 1989
Externally publishedYes

Fingerprint

Spinal Nerves
Cytomegalovirus
Peripheral Nerves
Spinal Cord Diseases
Spinal Cord
Acquired Immunodeficiency Syndrome
HIV
Pathology
Antigens
Spinal Nerve Roots
Brain
Peripheral Nervous System Diseases
Immunoenzyme Techniques
Paraffin
Inflammation

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Spinal cord and peripheral nerve pathology in AIDS : The roles of cytomegalovirus and human immunodeficiency virus. / Grafe, Marjorie; Wiley, C. A.

In: Annals of Neurology, Vol. 25, No. 6, 1989, p. 561-566.

Research output: Contribution to journalArticle

@article{be46d4097e9f46078964247143ce7709,
title = "Spinal cord and peripheral nerve pathology in AIDS: The roles of cytomegalovirus and human immunodeficiency virus",
abstract = "We examined spinal cords, nerve roots, or peripheral nerves of 27 patients who died with acquired immunodeficiency syndrome (AIDS) for the presence of cytomegalovirus (CMV) and human immunodeficiency virus (HIV) by immunoperoxidase techniques in paraffin-embedded tissue. Vacuolar myelopathy was seen in 8 of 26 spinal cords (31{\%}) and microglial nodules were seen in 13 (50{\%}). All of the patients with lateral column vacuolar myelopathy showed severe brain pathology. HIV antigens had been detected in the brains of 15 (55{\%}) of the 27 patients but were detected in only 3 (11{\%}) of 26 spinal cords and were not localized to regions of vacuolar myelopathy. This suggests that the vacuolar myelopathy may be due to a remote or indirect effect of HIV or other infectious agent. CMV antigens were detected in none of the patients who showed vascuolar myelopathy but were detected in 2 of the 13 with microglial nodules. Focal nerve root or peripheral nerve inflammation was seen in 7 patients; 4 had CMV antigens and none had HIV antigens. CMV appears to be an important cause of inflammatory peripheral neuropathy in AIDS patients.",
author = "Marjorie Grafe and Wiley, {C. A.}",
year = "1989",
language = "English (US)",
volume = "25",
pages = "561--566",
journal = "Annals of Neurology",
issn = "0364-5134",
publisher = "John Wiley and Sons Inc.",
number = "6",

}

TY - JOUR

T1 - Spinal cord and peripheral nerve pathology in AIDS

T2 - The roles of cytomegalovirus and human immunodeficiency virus

AU - Grafe, Marjorie

AU - Wiley, C. A.

PY - 1989

Y1 - 1989

N2 - We examined spinal cords, nerve roots, or peripheral nerves of 27 patients who died with acquired immunodeficiency syndrome (AIDS) for the presence of cytomegalovirus (CMV) and human immunodeficiency virus (HIV) by immunoperoxidase techniques in paraffin-embedded tissue. Vacuolar myelopathy was seen in 8 of 26 spinal cords (31%) and microglial nodules were seen in 13 (50%). All of the patients with lateral column vacuolar myelopathy showed severe brain pathology. HIV antigens had been detected in the brains of 15 (55%) of the 27 patients but were detected in only 3 (11%) of 26 spinal cords and were not localized to regions of vacuolar myelopathy. This suggests that the vacuolar myelopathy may be due to a remote or indirect effect of HIV or other infectious agent. CMV antigens were detected in none of the patients who showed vascuolar myelopathy but were detected in 2 of the 13 with microglial nodules. Focal nerve root or peripheral nerve inflammation was seen in 7 patients; 4 had CMV antigens and none had HIV antigens. CMV appears to be an important cause of inflammatory peripheral neuropathy in AIDS patients.

AB - We examined spinal cords, nerve roots, or peripheral nerves of 27 patients who died with acquired immunodeficiency syndrome (AIDS) for the presence of cytomegalovirus (CMV) and human immunodeficiency virus (HIV) by immunoperoxidase techniques in paraffin-embedded tissue. Vacuolar myelopathy was seen in 8 of 26 spinal cords (31%) and microglial nodules were seen in 13 (50%). All of the patients with lateral column vacuolar myelopathy showed severe brain pathology. HIV antigens had been detected in the brains of 15 (55%) of the 27 patients but were detected in only 3 (11%) of 26 spinal cords and were not localized to regions of vacuolar myelopathy. This suggests that the vacuolar myelopathy may be due to a remote or indirect effect of HIV or other infectious agent. CMV antigens were detected in none of the patients who showed vascuolar myelopathy but were detected in 2 of the 13 with microglial nodules. Focal nerve root or peripheral nerve inflammation was seen in 7 patients; 4 had CMV antigens and none had HIV antigens. CMV appears to be an important cause of inflammatory peripheral neuropathy in AIDS patients.

UR - http://www.scopus.com/inward/record.url?scp=0024324888&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0024324888&partnerID=8YFLogxK

M3 - Article

C2 - 2545160

AN - SCOPUS:0024324888

VL - 25

SP - 561

EP - 566

JO - Annals of Neurology

JF - Annals of Neurology

SN - 0364-5134

IS - 6

ER -