Spectral domain optical coherence tomographic imaging of geographic atrophy

Brandon J. Lujan; Philip J. Rosenfeld; Giovanni Gregori; Fenghua Wang; Robert W. Knighton; William J. Feuer; Carmen A. Puliafito

Spectral domain optical coherence tomographic imaging of geographic atrophy

Brandon J. Lujan, Philip J. Rosenfeld, Giovanni Gregori, Fenghua Wang, Robert W. Knighton, William J. Feuer, Carmen A. Puliafito

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

Background and Objectives: To compare images of geographic atrophy (GA) obtained using spectral domain optical coherence tomography (SD-OCT) with images obtained using fundus autofluorescence (FAF). Patients and Methods: Five eyes from patients with dry AMD were imaged using SD-OCT and FAF, and the size and shape of the GA were compared. Result: GA appears bright on SD-OCT compared with the surrounding areas with an intact retinal pigment epithelium because of increased reflectivity from the underlying choroid. SD-OCT and FAF both identified GA reproducibly, and measurement of the area of GA is comparable between the two methods with a mean difference of 2.7% of the total area. Conclusion: SD-OCT can identify and quantitate areas of GA. The size and shape of these areas correlate well to the areas of GA seen on autofluorescence images; however, SD-OCT imaging also provides important cross-sectional anatomic information.

Original language	English (US)
Pages (from-to)	S8-S14
Journal	Ophthalmic Surgery Lasers and Imaging
Volume	39
Issue number	4 SUPPL.
State	Published - Jul 1 2008
Externally published	Yes

ASJC Scopus subject areas

Surgery
Ophthalmology

Cite this

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title = "Spectral domain optical coherence tomographic imaging of geographic atrophy",

abstract = "Background and Objectives: To compare images of geographic atrophy (GA) obtained using spectral domain optical coherence tomography (SD-OCT) with images obtained using fundus autofluorescence (FAF). Patients and Methods: Five eyes from patients with dry AMD were imaged using SD-OCT and FAF, and the size and shape of the GA were compared. Result: GA appears bright on SD-OCT compared with the surrounding areas with an intact retinal pigment epithelium because of increased reflectivity from the underlying choroid. SD-OCT and FAF both identified GA reproducibly, and measurement of the area of GA is comparable between the two methods with a mean difference of 2.7% of the total area. Conclusion: SD-OCT can identify and quantitate areas of GA. The size and shape of these areas correlate well to the areas of GA seen on autofluorescence images; however, SD-OCT imaging also provides important cross-sectional anatomic information.",

author = "Lujan, {Brandon J.} and Rosenfeld, {Philip J.} and Giovanni Gregori and Fenghua Wang and Knighton, {Robert W.} and Feuer, {William J.} and Puliafito, {Carmen A.}",

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language = "English (US)",

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TY - JOUR

T1 - Spectral domain optical coherence tomographic imaging of geographic atrophy

AU - Lujan, Brandon J.

AU - Rosenfeld, Philip J.

AU - Gregori, Giovanni

AU - Wang, Fenghua

AU - Knighton, Robert W.

AU - Feuer, William J.

AU - Puliafito, Carmen A.

PY - 2008/7/1

Y1 - 2008/7/1

N2 - Background and Objectives: To compare images of geographic atrophy (GA) obtained using spectral domain optical coherence tomography (SD-OCT) with images obtained using fundus autofluorescence (FAF). Patients and Methods: Five eyes from patients with dry AMD were imaged using SD-OCT and FAF, and the size and shape of the GA were compared. Result: GA appears bright on SD-OCT compared with the surrounding areas with an intact retinal pigment epithelium because of increased reflectivity from the underlying choroid. SD-OCT and FAF both identified GA reproducibly, and measurement of the area of GA is comparable between the two methods with a mean difference of 2.7% of the total area. Conclusion: SD-OCT can identify and quantitate areas of GA. The size and shape of these areas correlate well to the areas of GA seen on autofluorescence images; however, SD-OCT imaging also provides important cross-sectional anatomic information.

AB - Background and Objectives: To compare images of geographic atrophy (GA) obtained using spectral domain optical coherence tomography (SD-OCT) with images obtained using fundus autofluorescence (FAF). Patients and Methods: Five eyes from patients with dry AMD were imaged using SD-OCT and FAF, and the size and shape of the GA were compared. Result: GA appears bright on SD-OCT compared with the surrounding areas with an intact retinal pigment epithelium because of increased reflectivity from the underlying choroid. SD-OCT and FAF both identified GA reproducibly, and measurement of the area of GA is comparable between the two methods with a mean difference of 2.7% of the total area. Conclusion: SD-OCT can identify and quantitate areas of GA. The size and shape of these areas correlate well to the areas of GA seen on autofluorescence images; however, SD-OCT imaging also provides important cross-sectional anatomic information.

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Spectral domain optical coherence tomographic imaging of geographic atrophy

Abstract

ASJC Scopus subject areas

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