Specific opioid-amphetamine interactions in the caudate putamen

S. K. Woo, Robert Hitzemann, H. H. Loh

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Bilateral microinjection of morphine (0.003-3 μg/side) into the caudate putamen enhances the behavior induced by the IP injection of 1 mg/kg d-amphetamine phosphate in a dose-related manner. The duration of activity was prolonged and ambulation was changed to d-amphetamine stereotypy, a behavior normally associated with higher doses of d-amphetamine. The opioid activity was stereospecific in that levorphanol was active, whereas dextrorphan was not. The enhancement of d-amphetamine-induced behavior by the opioids was blocked by naloxone. d-ala2-met-Enkephalin also enhanced the amphetamine-induced behavior. This enhancement appears to be specific to the caudate putamen because the oral stereotypy observed appears to be a unique action of amphetamine in this region of the brain.

Original languageEnglish (US)
Pages (from-to)371-376
Number of pages6
JournalPsychopharmacology
Volume85
Issue number3
DOIs
StatePublished - Mar 1985
Externally publishedYes

Fingerprint

Dextroamphetamine
Putamen
Amphetamine
Opioid Analgesics
Levorphanol
Dextrorphan
Methionine Enkephalin
Microinjections
Naloxone
Morphine
Walking
Phosphates
Injections
Brain

Keywords

  • Behavior
  • Caudate putamen
  • d-ala-met-Enkephalin
  • d-Amphetamine
  • Dopamine
  • Morphine

ASJC Scopus subject areas

  • Pharmacology

Cite this

Specific opioid-amphetamine interactions in the caudate putamen. / Woo, S. K.; Hitzemann, Robert; Loh, H. H.

In: Psychopharmacology, Vol. 85, No. 3, 03.1985, p. 371-376.

Research output: Contribution to journalArticle

Woo, S. K. ; Hitzemann, Robert ; Loh, H. H. / Specific opioid-amphetamine interactions in the caudate putamen. In: Psychopharmacology. 1985 ; Vol. 85, No. 3. pp. 371-376.
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