Species and sex differences in brain distribution of corticotropin- releasing factor receptor subtypes 1 and 2 in monogamous and promiscuous vole species

Miranda Lim, Hemanth P. Nair, Larry J. Young

Research output: Contribution to journalArticle

67 Citations (Scopus)

Abstract

Corticotropin-releasing factor (CRF) receptor subtypes 1 and 2 have been implicated in rodent models of anxiety, but much less is known about the CRF system and social behavior. Both corticosterone and central CRF receptors modulate pair bonding in the monogamous prairie vole. Using receptor autoradiography, we mapped CRFR1 and CRFR2 in the brains of two monogamous vole species, the prairie vole and pine vole, and two promiscuous vole species, the meadow vole and montane vole. We found markedly different patterns of brain CRFR1 and CRFR2 binding among the four species, including species differences in the olfactory bulb, nucleus accumbens, lateral septum, hippocampus, laterodorsal thalamus, cingulate cortex, superior colliculus, and dorsal raphe. Interestingly, we also observed striking sex differences in voles: CRFR2 binding was higher in the encapsulated bed nucleus of the stria terminalis in males than females for all four vole species. These results suggest possible sites of action for CRF-induced facilitation of pair bond formation in prairie voles, as well as potential sex differences in the CRF modulation of pair bonding. Further examination of CRF receptors in vole species may reveal a novel role for CRF in social behavior. Ultimately, our results identify several brain regions with conserved CRF receptor patterns across rodent and primate species, in contrast to several brain regions with phylogenetically plastic CRF receptor patterns, and have interesting implications for the evolution of CRF receptor patterns and behavior.

Original languageEnglish (US)
Pages (from-to)75-92
Number of pages18
JournalJournal of Comparative Neurology
Volume487
Issue number1
DOIs
StatePublished - Jun 20 2005
Externally publishedYes

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Arvicolinae
Sex Characteristics
Corticotropin-Releasing Hormone Receptors
Brain
Corticotropin-Releasing Hormone
Social Behavior
Rodentia
CRF receptor type 2
CRF receptor type 1
Pair Bond
Septal Nuclei
Superior Colliculi
Olfactory Bulb
Gyrus Cinguli
Nucleus Accumbens
Corticosterone
Autoradiography
Thalamus
Primates
Plastics

Keywords

  • Bed nucleus of the stria terminalis
  • Corticotrophin-releasing hormone
  • Corticotropin-releasing factor
  • Hippocampus
  • Lateral septum
  • Nucleus accumbens

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Species and sex differences in brain distribution of corticotropin- releasing factor receptor subtypes 1 and 2 in monogamous and promiscuous vole species. / Lim, Miranda; Nair, Hemanth P.; Young, Larry J.

In: Journal of Comparative Neurology, Vol. 487, No. 1, 20.06.2005, p. 75-92.

Research output: Contribution to journalArticle

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