Sources of carrier F-19 in F-18 fluoride

J. M. Link, S. C. Shoner, K. A. Krohn

Research output: Chapter in Book/Report/Conference proceedingConference contribution

4 Scopus citations

Abstract

Fluorine-18 is used for many PET radiopharmaceuticals. Theoretically 18F should be carrier free and a good candidate for nanochemistry. However, 18F has 10 to 1000 times more stable fluorine atoms than radioactive atoms. In order to understand the source of carrier fluoride and other ions associated with 18F radiosynthesis, anion concentrations of different components of 18F target systems as well as solvents and chemicals used in radiosynthesis were measured. Results: The enriched water used for production of 18F had low levels of anions. In general, the sources of anions, particularly of fluoride, were the chemical reagents used for synthesis and trace contaminants in tubing, valves and fittings. A major component of contamination was nitrate from irradiation of dissolved nitrogen gas in the target water.

Original languageEnglish (US)
Title of host publication14th International Workshop on Targetry and Target Chemistry
Pages61-65
Number of pages5
DOIs
StatePublished - Dec 1 2012
Event14th International Workshop on Targetry and Target Chemistry, WTTC 2012 - Playa del Carmen, Mexico
Duration: Aug 26 2012Aug 29 2012

Publication series

NameAIP Conference Proceedings
Volume1509
ISSN (Print)0094-243X
ISSN (Electronic)1551-7616

Other

Other14th International Workshop on Targetry and Target Chemistry, WTTC 2012
CountryMexico
CityPlaya del Carmen
Period8/26/128/29/12

Keywords

  • PET
  • fluorine-18
  • radionuclide
  • specific activity

ASJC Scopus subject areas

  • Physics and Astronomy(all)

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  • Cite this

    Link, J. M., Shoner, S. C., & Krohn, K. A. (2012). Sources of carrier F-19 in F-18 fluoride. In 14th International Workshop on Targetry and Target Chemistry (pp. 61-65). (AIP Conference Proceedings; Vol. 1509). https://doi.org/10.1063/1.4773941