Sodium valproic in the treatment of cerebellar disorders

A. N. Neophytides, P. F. Teychenne, Ronald Pfeiffer, D. B. Calne

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Because of the high concentrations of γ-aminobutyric acid (GABA) in the cerebellar cortex and nuclei, an attempt was made to enhance GABAergic transmission in patients with cerebellar disease. Maximum tolerated doses of sodium valproate, a drug which inhibits the degradation of GABA, failed to influence cerebellar deficits in a double blind crossover study on six patients.

Original languageEnglish (US)
Pages (from-to)455-457
Number of pages3
JournalCanadian Journal of Neurological Sciences
Volume6
Issue number4
StatePublished - 1979
Externally publishedYes

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Cerebellar Diseases
gamma-Aminobutyric Acid
Sodium
Aminobutyrates
Cerebellar Nuclei
Cerebellar Cortex
Maximum Tolerated Dose
Valproic Acid
Double-Blind Method
Cross-Over Studies
Therapeutics
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

Cite this

Neophytides, A. N., Teychenne, P. F., Pfeiffer, R., & Calne, D. B. (1979). Sodium valproic in the treatment of cerebellar disorders. Canadian Journal of Neurological Sciences, 6(4), 455-457.

Sodium valproic in the treatment of cerebellar disorders. / Neophytides, A. N.; Teychenne, P. F.; Pfeiffer, Ronald; Calne, D. B.

In: Canadian Journal of Neurological Sciences, Vol. 6, No. 4, 1979, p. 455-457.

Research output: Contribution to journalArticle

Neophytides, AN, Teychenne, PF, Pfeiffer, R & Calne, DB 1979, 'Sodium valproic in the treatment of cerebellar disorders', Canadian Journal of Neurological Sciences, vol. 6, no. 4, pp. 455-457.
Neophytides, A. N. ; Teychenne, P. F. ; Pfeiffer, Ronald ; Calne, D. B. / Sodium valproic in the treatment of cerebellar disorders. In: Canadian Journal of Neurological Sciences. 1979 ; Vol. 6, No. 4. pp. 455-457.
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