Because of the high concentrations of ɣ-aminobutyric acid (GABA) in the cerebellar cortex and nuclei, an attempt was made to enhance GABAergic transmission in patients with cerebellar disease. Maximum tolerated doses of sodium valproate, a drug which inhibits the degradation of GABA, failed to influence cerebellar deficits in a double blind crossover study on six patients.
|Original language||English (US)|
|Number of pages||3|
|Journal||Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques|
|State||Published - Nov 1979|
ASJC Scopus subject areas
- Clinical Neurology