Sodium Valproate in the Treatment of Cerebellar Disorders

Andreas N. Neophytides; Paul F. Teychenne; Ronald F. Pfeiffer; Donald B. Calne

doi:10.1017/S031716710002388X

Sodium Valproate in the Treatment of Cerebellar Disorders

Andreas N. Neophytides, Paul F. Teychenne, Ronald F. Pfeiffer, Donald B. Calne

Neurology

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

Because of the high concentrations of ɣ-aminobutyric acid (GABA) in the cerebellar cortex and nuclei, an attempt was made to enhance GABAergic transmission in patients with cerebellar disease. Maximum tolerated doses of sodium valproate, a drug which inhibits the degradation of GABA, failed to influence cerebellar deficits in a double blind crossover study on six patients.

Original language	English (US)
Pages (from-to)	455-457
Number of pages	3
Journal	Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques
Volume	6
Issue number	4
DOIs	https://doi.org/10.1017/S031716710002388X
State	Published - Nov 1979

ASJC Scopus subject areas

Neurology
Clinical Neurology

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10.1017/S031716710002388X

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title = "Sodium Valproate in the Treatment of Cerebellar Disorders",

abstract = "Because of the high concentrations of ɣ-aminobutyric acid (GABA) in the cerebellar cortex and nuclei, an attempt was made to enhance GABAergic transmission in patients with cerebellar disease. Maximum tolerated doses of sodium valproate, a drug which inhibits the degradation of GABA, failed to influence cerebellar deficits in a double blind crossover study on six patients.",

author = "Neophytides, {Andreas N.} and Teychenne, {Paul F.} and Pfeiffer, {Ronald F.} and Calne, {Donald B.}",

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AU - Pfeiffer, Ronald F.

AU - Calne, Donald B.

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AB - Because of the high concentrations of ɣ-aminobutyric acid (GABA) in the cerebellar cortex and nuclei, an attempt was made to enhance GABAergic transmission in patients with cerebellar disease. Maximum tolerated doses of sodium valproate, a drug which inhibits the degradation of GABA, failed to influence cerebellar deficits in a double blind crossover study on six patients.

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Sodium Valproate in the Treatment of Cerebellar Disorders

Abstract

ASJC Scopus subject areas

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