Sodium Valproate in the Treatment of Cerebellar Disorders

Andreas N. Neophytides, Paul F. Teychenne, Ronald F. Pfeiffer, Donald B. Calne

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

Because of the high concentrations of ɣ-aminobutyric acid (GABA) in the cerebellar cortex and nuclei, an attempt was made to enhance GABAergic transmission in patients with cerebellar disease. Maximum tolerated doses of sodium valproate, a drug which inhibits the degradation of GABA, failed to influence cerebellar deficits in a double blind crossover study on six patients.

Original languageEnglish (US)
Pages (from-to)455-457
Number of pages3
JournalCanadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques
Volume6
Issue number4
DOIs
StatePublished - Nov 1979

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ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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